ABSTRACT
Objective To investigate the dynamic changes of infection distribution ,current resistance situation of Streptococcus pneumoniae(SP) in Sichuan area for the guidance of clinical therapy of SP .Methods The clinical result of SP from January 2013 to June 2016 were collected in our hospital .The age ,distribution department ,sample type ,the season and drug susceptibility results were analyzed .Results Infections caused by SP was prevalent in spring and winter ,and which mainly occurred in the infant and the elderly .The number of SP was maximum in the pediatrics ,and the detection rate was above 59% .Clinical isolates of SP mainly were detected from sputum ,followed by the blood .Penicillin G‐resistant SP strains were isolated more and more from 2013 to 2016 in Si‐chuan area .Erythromycin(E) ,Tetracycline(TC) and Trimethoprim/Sulfamethoxazole(SXT) had the higher resistance .No drug‐re‐sistant strains of Vancomycin(VA) and Linezolid(LZD) were detected .Levofloxacin(LEV) and Moxifloxacin(MXF) were more sensitive ,being more 95% ,and the sensitive rate of Chlormycetin(CL) also was over 87% .Conclusion There is an upward trend to detect the penicillin G‐resistant SP strains .Using of E ,TC and SXT should be managed ,because of its higher resisitance rate .How‐ever ,LEV ,MXF ,VA and LZD could still be used by clinical doctors for its higher sensitive rate .