ABSTRACT
Objective To explore the clinical and pathological features of carcinoma in bladder diverticulum,and its diagnosis and treatment. Methods This series included 5 cases of carcinomas in bladder diverticula (male,4 and female 1;mean age,73 years).Three cases were pre-operatively confirmed by biopsy with cystoscopy,and 2 were intra-operatively confirmed by frozen section of samples.Of the 5 cases,2 of transitional cell carcinoma underwent partial cystectomy;the remaining 3,each of whom had squamous cell carcinoma,adenocarcinoma and mixed carcinoma (squamous cell carcinoma and transitional cell carcinoma),underwent radical cystectomy and ileal neobladder.After operation 3 cases received chemotherapy,1 case received chemotherapy and radiotherapy. Results The 5 cases were followed up for an average of 23 months (6～72 months).Two cases of transitional cell carcinoma had relapse,and then underwent radical cystectomy and ileal neobladder.Of them 1 died of distant metastasis soon after operation,the other had survived free of tumor for 6 years since operation.The case of squamous cell carcinoma died of multiorgan metastasis 14 months after operation.The case of adenocarcinoma died of myocardial infarction 11 months after operation.The case of mixed carcinoma had survived free of tumor for 6 months since operation. Conclusions Cystoscopy and imaging play an important role in detecting tumors originating from the bladder diverticulum.Surgical operation,especially radical cystectomy,should be performed.Adjunctive therapies such as chemotherapy and radiotherapy can be conducted if necessary.