ABSTRACT
Hydrogel posses a degree of flexibility very similar to natural tissues, due to their significant water content. Thus they find potential biomedical applications owing to their excellent bio-compatibility, bio degradability and non toxicity. The main highlight of the work is that it is taking naturally occurring polymers such as agar and Chitosan for the synthesis of hydrogel. Different compositions of Chitosan/Agar hydrogels were formulated and optimised with respect to pH sensing, Urea absorption and dye adsorption. Chitosan/Agar hydrogels are found to be suitable and a potential candidate for several agricultural and bio medical applications
ABSTRACT
BACKGROUND: Mental retardation (MR) is a heterogeneous dysfunction of the central nervous system exhibiting complex phenotypes and has an estimated prevalence of 1-3% in the general population. However, in about 50% of the children diagnosed with any form of intellectual disability or developmental delay the cause goes undetected contributing to idiopathic intellectual disability. MATERIALS AND METHODS: A total of 122 children with developmental delay/MR were studied to identify the microscopic and submicroscopic chromosome rearrangements by using the conventional cytogenetics and multiplex ligation dependent probe amplification (MLPA) analysis using SALSA MLPA kits from Microbiology Research Centre Holland [MRC] Holland. RESULTS: All the recruited children were selected for this study, after thorough clinical assessment and metaphases prepared were analyzed by using automated karyotyping system. None was found to have chromosomal abnormality; MLPA analysis was carried out in all subjects and identified in 11 (9%) patients. CONCLUSION: Karyotype analysis in combination with MLPA assays for submicroscopic micro-deletions may be recommended for children with idiopathic MR.