ABSTRACT
Pancuronium is one of the most available nondepolarizing muscle relaxant. It is primarily eliminat-ed unchanged by the kidney, although a small fraction is metabolized by the liver. On the other hand, calcium channel blocking agents are a chemically heterogeneous group of drugs that inhibit the ionic current carried through the calcium slow channel in cardiac and vascular smooth muscle. This action is the basis of their usefulness in the treatment of cardiovascular disorders. Although the role of calcium in skeletal muscle differs from that in cardiac and vascular smooth muscle, various recent studies have shown that verapamil is able to inhibit neuromuscular function in skeletal muscle preparations. However, it is not well known, yet. Increasing number of patients who are taking calcium channel blockers were reported recently. The present study was undertaken to determine if verapamil could potentiate the effects on pancuronium and how does it affect the cardiovacular response. The results were as follows; 1. Verapamil (1.41 mg) significantly enhanced the recovery index of pancuronium as 226.7 sec compared with control recovery index as 162.5 sec (p<0.025). But tetanic stimulation (50Hz, 5 sec) was sustained in the both group. 2. Hypotensive effect was appeared when 1.41 mg of verapamil was given and it was taken 7.7 min. 3. Signs of cardiovascular response was decreasing the blood pressure especially diastolic first then heart rate was decreased.
Subject(s)
Humans , Rabbits , Blood Pressure , Calcium , Calcium Channel Blockers , Calcium Channels , Hand , Heart Rate , Kidney , Liver , Muscle Relaxation , Muscle, Skeletal , Muscle, Smooth, Vascular , Pancuronium , VerapamilABSTRACT
Pancuronium is one of the most available nondepolarizing muscle relaxant. It is primarily eliminat-ed unchanged by the kidney, although a small fraction is metabolized by the liver. On the other hand, calcium channel blocking agents are a chemically heterogeneous group of drugs that inhibit the ionic current carried through the calcium slow channel in cardiac and vascular smooth muscle. This action is the basis of their usefulness in the treatment of cardiovascular disorders. Although the role of calcium in skeletal muscle differs from that in cardiac and vascular smooth muscle, various recent studies have shown that verapamil is able to inhibit neuromuscular function in skeletal muscle preparations. However, it is not well known, yet. Increasing number of patients who are taking calcium channel blockers were reported recently. The present study was undertaken to determine if verapamil could potentiate the effects on pancuronium and how does it affect the cardiovacular response. The results were as follows; 1. Verapamil (1.41 mg) significantly enhanced the recovery index of pancuronium as 226.7 sec compared with control recovery index as 162.5 sec (p<0.025). But tetanic stimulation (50Hz, 5 sec) was sustained in the both group. 2. Hypotensive effect was appeared when 1.41 mg of verapamil was given and it was taken 7.7 min. 3. Signs of cardiovascular response was decreasing the blood pressure especially diastolic first then heart rate was decreased.