ABSTRACT
PURPOSE: The aim of this experimental study is to observe the effect of platelet-rich plasma (PRP) on early bone regeneration of rats both in normal condition and in osteoporosis induced by ovariectomy. MATERIAL AND METHODS: Total 40 Sprague-Dawley female rats were divided into 4 groups. A 8-mm-diameter calvarial critical-sized defect (CSD) was made by drilling with trephine at the center of calvaria in cranium of every rat. Every CSD was augmented with an osteoconductive synthetic alloplastic substitute (MBCP(TM)) and PRP as follows. Group A; 10 non-ovariectomized rats grafted with only MBCP(TM). Group B; 10 non-ovariectomized rats grafted with MBCP(TM)and PRP. Group C; 10 ovariectomized rats grafted with only MBCP(TM). Group D; 10 ovariectomized rats grafted with MBCP(TM) and PRP. At 4 weeks after graft, every rat was sacrificed. And histomorphometric analysis was performed by measuring calcified area of new bone formation within the CSD. RESULTS: Comparing four groups, results were obtained as follows. 1. In non-ovariectomized groups, PRP showed a positive effect somewhat but not significant (P > .05). 2. In ovariectomized groups, PRP showed a positive effect significantly (P .05). CONCLUSION: Within the limitation of this study, it can be concluded that PRP in combination with an osteoconductive synthetic alloplastic substitute has an effect on bone regeneration more significantly in ovariectomized osteoporotic rats than in normal rats.