ABSTRACT
OBJECTIVE: To investigate a suitable animal model for studies of male osteoporosis. Osteoporosis has a particularly high incidence in postmenopausal women, resulting in a substantial amount of research with respect to this disease in women. However, research on osteoporosis in men is still lacking. METHODS: Twenty 10-week-old male Sprague Dawley rats were used in this study, including 4 rats used to establish a baseline bone mineral density (BMD). The other 16 rats were divided into two groups: a sham surgery group (n=8), which underwent a sham operation, and an orchiectomized rat group (OCX) (n=8), which underwent bilateral OCX at 10 weeks of age. Bone mineral density was measured in 4 rats from both the sham surgery group and the OCX group 8 weeks after the surgery, while BMD in the remainder of the rats was measured 10 weeks post-surgery. RESULTS: Femoral BMD at 8 weeks post-surgery was found to be significantly lower in the OCX group compared to the sham group; a finding that was also similar 10 weeks post-surgery. CONCLUSION: 8 weeks after undergoing orchiectomy performed via a scrotal, white rats are a suitable model for studies of male osteoporosis.
Subject(s)
Animals , Female , Humans , Male , Rats , Bone Density , Femur , Incidence , Models, Animal , Multiple Endocrine Neoplasia Type 1 , Orchiectomy , Osteoporosis , Rats, Sprague-DawleyABSTRACT
OBJECTIVE: The purpose of this study is to evaluate the clinical and radiographic results of infective atlantoaxial subluxation, and to describe the management of pyogenic or tuberculosis atlantoaxial subluxation. METHODS: In this study, we present seven patients with atlantoaxial subluxation after pyogenic or tuberculosis vertebral osteomyelitis. Prominent manifestations included neck pain and stiffness, swelling of the retropharyngeal soft tissues, quadriparesis, and osteolytic erosions. All patients received antibiotics/antituberculosis medication. One patient was managed conservatively, two underwent only transoral biopsy, one patient underwent transoral decompression and posterior fusion, and three patients underwent only posterior fusion. RESULTS: All patients showed significant improvement in neck pain and neck movement. Three patients who showed quadriparesis or motor weakness at the time of diagnosis showed improvement in motor strength, although subjective weakness persisted in two patients. CONCLUSION: In our study, we describe the management of this disease at our institute. Available treatment modalities vary from purely conservative medical management to surgical correction. Medical treatment is the mainstay of management. The need for and the extent of surgery are dependent on the presence of instability and spinal cord compression and should be determined on a case by case basis.
Subject(s)
Humans , Atlanto-Axial Joint , Biopsy , Decompression , Neck , Neck Pain , Osteomyelitis , Quadriplegia , Spinal Cord Compression , Spinal Cord Injuries , Trauma, Nervous System , TuberculosisABSTRACT
Spontaneous spinal epidural hematoma (SSEH) has been rarely reported in the literature. Prompt surgical intervention is recommended for patients with neurologic deficit. However. in rare cases, spontaneous resolution of the SSEH with recovery of the neurological deficit has also been reported. We report a case of SSEH in a 55-year-old woman with a rapidly progressing neurological deficit. Her neurological deficits gradually improved sponta- neously during preoperative evaluation. Serial magnetic resonance imaging(MRI) demonstrated disappearance of the hematoma. Since her neurological status improved within a few hours, we recommended conservative care. Patients initially presenting with severe neurologic dysfunction are potential candidates for conservative management if they demonstrate rapid and progressive improvement in neurologic function. Thus, immediate surgical decompression may not be necessary if neuroimaging and clinical examinations suggest that spinal epidural hematoma will spontaneously resolve.
Subject(s)
Female , Humans , Middle Aged , Decompression, Surgical , Hematoma , Hematoma, Epidural, Spinal , Magnetic Resonance Spectroscopy , Neuroimaging , Neurologic ManifestationsABSTRACT
Bronchial foreign body is not a rare disease in children and it is urgently necessary to remove this foreign body from the airway to relive life or to prevent further damages and complications. But the innate small size of airways in infants makes it difficult to access by interventional methods such as intubation or bronchoscopy and etc. Laryngeal mask airway is a new way of method of airway management which is relatively recently introduced into medical practice. It gives way to access to airways without reducing the size of airway or incresing airway pressure during procedure through it and have many other advantages compared to the previous traditional endotracheal intubation, especially in infants. We successfully removed a case of bronchial foreign body, peanut, via laryngeal mask airway during fiberoptic bronchoscopy and by this method we can avoid the unnecessary tracheostomy in this 1 year old infant.