Histopathologic Study on the Effect of Tracheal Mucosa after Inhalation of O-Chlorobenzylidene Malononitrile(CS) in the Rats / 대한이비인후과학회지

This study was undertaken to investigate the histopathological change in the tracheal mucosa of rats by light microscope following acute exposure to ortho-chlorobenzylidene malononitrile(CS). 2.0g/m3 of CS was inhalated to experimental rats for 20 minutes per day during 3 days in a plastic chamber. The experimental animals were sacrificed at 12 hours, 24 hours, 3 days, and 5 days after CS gas exposure. Specimens were obtained from upper most part of tracheal mucosa of the rats. After H and E stain and PAS stain were performed, all specimens were observed by light microscope. The result were as follows: 1) At 12 hours after exposure , there were some cilia destruction, widening of lamina propria, and infiltration of inflammatory cells in subepithelial layer. Epithelial lining and goblet cells were well preserved. 2) At 24 hours after exposure, epithelial lining and basement membrane were destructed and goblet cells were decreased in number. Infiltration of inflammatory cells in subepithelial layer were as sustained and vascular congestion was observed. 3) At 3 days after exposure, regeneration of epithelial layer, goblet cells, and basement membrane were identified. In subepithelial layer, a few inflammatory cells were infiltrated. 4) At 5 days after exposure, intact epithelial layer and numerous normal goblet cells were appeared. Lamina propria was narrowed and no inflammatory cells were in subepithelial layer. The results suggested that the tracheal mucosa of the rats shows a siginificant degenerative change after acute exposure to ortho-chlorobenzylidene malononitirile. However, it was temporary and reversible change.

A Case of Verrucous Carcinoma of Base of Tongue / 대한이비인후과학회지

Verrucous carcinoma is simply very well differentiated malignant neoplasm. It is unique only in that the diagnosis is difficult to make histologically and locally invasive but metastasis is rare. Clinically, verrucous carcinoma is often warty and usually exophytic. It can be multicentric. It looks uniquely epithelial. When biopsy is done, the pathologist uses words such as "hyperplasia", "keratosis" or "fibrosis", however is reluctant to use the word "carcinoma". Verrrucous carcinoma can be present in three forms: oral or mucosal, genital, and plantar. Base of tongue is uncommon site in it. Authors are reporting a case of huge verrucous carcinoma of base of tongue with a view of the related articles.