ABSTRACT
Focal acral hyperkeratosis (FAH) is a rare genodermatosis inherited by autosomal dominant transmission; however, some sporadic cases have also been reported. FAH is characterized by multiple late-onset crateriform hyperkeratotic papules with a yellow color on the border of the hands and feet. A 31-year-old man presented with yellowish discrete flat-topped papules on the lateral side of his palms and fingers. The patient had a family history of similar lesions throughout three generations. The histological findings revealed hyperkeratosis with mild hypergranulosis in the epidermis, and the dermis showed no specific changes including elastorrhexis. These clinicopathologic findings were consistent with the diagnosis of FAH. Herein, we report a rare case of FAH with autosomal dominant inheritance.
Subject(s)
Adult , Humans , Dermis , Diagnosis , Epidermis , Family Characteristics , Fingers , Foot , Hand , WillsABSTRACT
No abstract available.
Subject(s)
Humans , Infant , Male , Urticaria Pigmentosa , UrticariaABSTRACT
BACKGROUND: Onychomycosis is one of the most prevalent fungal diseases in the general population. However, treatment is of limited effectiveness and must be administered for long periods of time. Systemic antifungal agents are associated with adverse effects. OBJECTIVE: We evaluated the clinical efficacy and safety of a 1,064-nm neodymium-doped yttrium aluminium garnet (Nd:YAG) laser with amorolfine nail lacquer to treat onychomycosis. METHODS: The 128 patients were randomly divided to 2 groups: 64 in the experimental group were treated with 1,064-nm Nd:YAG laser therapy and amorolfine nail lacquer; the other 64 were in a control group treated with topical amorolfine lacquer monotherapy. The laser treatment was 4 sessions at 4-week intervals and amorolfine lacquer was applied once a week for 16 weeks. Efficacy was assessed as response rate from standardized photographs with ImagePro®Plus (Media Cybernetics, Inc., USA) analysis, microscopic examination, and subjective evaluation. RESULTS: At 16 weeks, the experimental group showed a significantly higher cumulative cure rate than the control group (71.88% vs. 20.31%, p<0.0001). Clinical therapeutic effects were linked to patient satisfaction. The percent of “very satisfied” or “satisfied” responses was higher in the test group than the control group (81.25% vs. 23.44%). The treatment regimen was well tolerated, with transient discomfort observed in the test group. CONCLUSION: The 1,064-nm Nd:YAG laser with amorolfine nail lacquer was effective and safe for treating onychomycosis. This therapy should be considered an alternative treatment, especially for patients with contraindications to systemic antifungal agents.
Subject(s)
Humans , Antifungal Agents , Cybernetics , Lacquer , Laser Therapy , Onychomycosis , Patient Satisfaction , Therapeutic Uses , Treatment Outcome , YttriumABSTRACT
Dermatologists often treat patients with complications arising from illegal cosmetic practices. Large numbers of non-medical personnel who claim to be “beauty experts” currently offer laser treatment, surgery, or injections that result in serious complications. Here we report two cases of adverse events: one after epilation with an unidentified laser device and the other after rhytidectomy performed using an unproven surgical method. Dermatologists should be aware of these complications and be able to educate both patients and fellow doctors about the potential risks.
Subject(s)
Humans , Hair Removal , Methods , RhytidoplastyABSTRACT
Vernet syndrome associated with varicella zoster virus (VZV) has been rarely reported. The diagnosis is established based on typical symptoms such as dysphagia, hoarseness, and unilateral difficulty in neck movement. Lack of skin lesions is common and makes it harder to consider VZV infection. A 53-year-old woman presented with left neck pain, dysphagia, hoarseness, and headache, with an erythematous vesicle on her neck. Laryngoscopy revealed paralysis of her left-soft palate and left-vocal cord. Upon cerebrospinal fluid (CSF) examination, her white blood cell (WBC) count, protein levels, glucose levels, and VZV antibody titer were elevated; moreover, VZV-DNA was detected. Magnetic resonance imaging (MRI) showed no sign of brain tumor, aneurysm or fracture. The patient was diagnosed with Vernet syndrome associated with VZV infection, having presented with a skin lesion involving the cervical segment.