ABSTRACT
The study has been conducted to find out the serum ADA levels in 120 patients with various pulmonary diseases which included patients with tubercular pleural effusion (n = 86), lung cancer (n = 10) and patients with non-tubercular pulmonary diseases like pneumonia, etc (n = 24). Twenty healthy individuals served as control subjects. The mean (+/- SD) of ADA activity was 23.38 (4.47), 7.29 (1.08), 12.71 (1.95) and 2.23 (1.00) units/litre in tuberculosis, malignancy, non-tubercular pulmonary diseases and healthy controls respectively with significant difference between each other (P less than 0.001). Patients with tuberculosis (100%) fall in 97% sensitivity range with a lower cut off limit at 17 units/litre ADA activity, while for malignancy and non-tubercular respiratory diseases, the sensitivity was 90% and 83% respectively. Within the sensitivity limits, the serum ADA activity can be used for the differential diagnosis of pulmonary diseases.
Subject(s)
Adenosine Deaminase/blood , Adolescent , Adult , Aged , Female , Humans , Lung Diseases/enzymology , Lung Neoplasms/enzymology , Male , Middle Aged , Tuberculosis, Pulmonary/enzymologyABSTRACT
When normal and alloxan-induced diabetic guineapigs were given whole seed diet of Phaseolus mungo (black gram) for 4 wk, the blood glucose, serum total lipids, triglycerides and esterified fraction of cholesterol were significantly lowered, while serum phospholipid was unaltered. Total cholesterol/phospholipid ratio also decreased in normal as well as diabetic animals indicating the antiatherogenic nature of P. mungo.
Subject(s)
Animals , Blood Glucose/analysis , Cholesterol/blood , Diabetes Mellitus, Experimental/blood , Diet , Fabaceae , Female , Guinea Pigs , Lipids/blood , Male , Plants, Medicinal , Triglycerides/bloodABSTRACT
Information available in literature is contradictory regarding the glycaemic and cholesterolaemic activities of various legume proteins. Present work deals with the study of the effect of 'Guar' feeding on serum total lipids, free and esterified cholesterol, triglycerides and phospholipids. Normal and alloxan induced diabetic guinea pigs were kept on the whole seed diet of 'Guar' for four weeks. Blood sugar and total lipid levels were found to be decreased significantly in normal and as well as diabetic animals; free and esterified cholesterol levels were also observed to be lowered significantly in normals, whereas esterified fraction alone was found to be lowered in diabetics. Significant fall in the levels of other lipids i.e., triglycerides, phospholipids and total lipids was also noticed.