Shortening Transfer Time of Critical Inpatients from Ward to Intensive Care Unit:Based on Six Sigma / 中国康复理论与实践

Objective To shorten the transfer time of critical inpatients from wards to intensive care unit (ICU). Methods From Novem-ber to December, 2015, 30 critical inpatients transferred from wards to ICU were investigated, and analyzed with Six Sigma DMAIC five-step method. There were 7 main processes and 22 sub-processes refined in transfer procedure, as well as the key quality points and the factors influencing the safety of transferring. Some improvement advice were recommended, including multifunctional transfer cart, Check-list before Transfer to Intensive Care Unit for Critical Patients, setting up transport group, training for young nurses and application of SBAR communication. Other 30 critical inpatients transferred from wards to ICU, from May to June, 2016, after the series of control pro-grams, were investigated. Results After improvement, the total transfer time from wards to ICU decreased (t=15.052, P<0.001), without the increase of human power and unsafety issues. The rescue success rate increased from 91.67%to 98.01%. Conclusion The process transfer-ring patient from wards to ICU has been reengineered based on Six Sigma DMAIC management, that reduces the time and improve the res-cue success rate.

Hypoxia promotes proliferation of rabbit mesenchymal stem cells / 基础医学与临床

Objective To investigate the effect of transition between hypoxia and normoxia on proliferation of rabbit mesenchymal stem cells(rMSCs).Methods rMSCs expanded in hypoxia were divided into two groups:L-L group and L-N group.Moreover,rMSCs expanded in normoxia were also divided into two groups:N-N group and N-L group.The L-L and N-L groups were subsequently subcultured in hypoxia,and L-N and N-N groups in normoxia.Growth curve,colony-forming efficiency,glucose and lactate metabolism,and intracellular ROS generation of the four groups were examined.Results In L-L group cell density and colony-forming efficiency were the highest,and intracellular ROS generation was the lowest,whereas reversed results were obtained in N-N group.Cells cultured in hypoxic conditions exhibited higher glucose consumption,lactate production and yield coefficients of lactate from glucose compared to normoxic ones.Conclusion Hypoxia may enhance the proliferation of rMSCs in continuous subcultures.There is a potential link between intracellular ROS generation and expansion of rMSCs.