ABSTRACT
Fructose-1, 6-diphosphate (FDP) is considered to be an effective agent for the relief of ischemia and vascular insufficiency. It is worthwhile to confirm this effect of FDP on platelet aggregation, fibrinolytic activity, platelet serotonin and plasma prostacyclin. This study was designed as a placebo-controlled, single-blind, crossover trial. There were 22 normal subjects: 12 males, 10 females with the age range of 21-40 years (mean = 32+6 years). A single FDP 150 mg/kg body weight dose was intravenously infused within 10 min. All the above parameters were assessed in all subjects before, and at ½ h and 6 h after the start of FDP. An equal volume of 10% glucose was used as the placebo in the same subjects in a similar manner. The results showed that FDP significantly inhibited platelet aggregation, increased both fibrinolytic activity and serotonin content in platelet. The interesting point is that FDP can maintain plasma prostacyclin for longer than 6 h after infusion. These considerable results indicated that FDP might be advantageous in relieving vascular occlusion or tissue ischemia in emergency patient. However more clinic trials of FDP are needed to confirm results.