ABSTRACT
Objective To analyze liver function damage and blood lipid difference in fatty liver patients of different ages.Methods From January 1,2016,to December 31,2017,a total of 15 163 non-alcoholic fatty liver (NAFLD) patients from the Changhai Hospital Medical Center were collected as NAFLD group,and 24 273 normal non-fatty liver patients were used as non-fatty liver group.The two groups were divided into 14 age groups.All age groups were stratified according to normal,abnormal and blood lipids,ideal,marginal and abnormal.The chi-square test was used to analyze the differences in liver function and blood lipids between age groups.Age and analysis of function and dyslipidemia rates and comparison between groups.Results There were differences in alanine aminotransferase (ALT) and aspartic acid aminotransferase (AST) levels between different fatty liver age groups (P＜0.05);x2 was 693.79 and 126.67,respectively.With the increase in age,ALT had a downward trend before the age of 69,and AST had a downward trend before the age of 49.The abnormal rate of ALT was ≥32.3％ in people under 24 years old,10.9％-28.5％ in people 25-54 years old and,≤8.7％ in people over 55 years old.The abnormal rate of AST was ≥30％ in people under 19 years old,10.6％-15.9％ in people 20-29 years old,and ≤7.8％ in people over 30 years old.The levels of high-density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),triacylglycerol (TG),and total cholesterol (TC) in non-alcoholic fatty liver disease of different age groups were statistically significant (x2=181.04,231.35,194.90,203.44,respectively,P＜0.05).The abnormal rates of HDL-C,LDL-C,TG,and TC were 30-34 years old,55-64 years old,45-49 years old,60-64 years old,respectively.The abnormal rate of HDL-C in the NAFLD group and the non-fitty liver group was 28.0％ and 3.4％,respectively,in 30-34 years old,LDL-C was 14.2％ and 4.7％,respectively,in 40-44 years old,and TG was 31.7％ and 4.9％,respectively,in 40-44 years old;the three age groups were the peak of the gap.The marginal rates of TG in the 30-34 age group NAFLD group and non-fitty liver group were 23.5％ and 5.5％,respectively,and it was most obvious in all age groups.Conclusion ALT and AST damage caused by NAFLD is most common in people under 54 years old and 29 years old,with abnormal rates of ≥10.9％ and ≥10.6％,respectively.The abnormal rate of blood lipids in NAFLD patients is higher than that in normal people.The abnormal rate of HDL-C is 30-34 years old,LDL-C is 40-44 years old and,TG is 40-44 years old.The marginal rate difference of TG in the 30-34 age group and the normal group was the most obvious.