ABSTRACT
Objective :To study influence of nicorandil on vascular endothelial function and serum inflammatory reac-tion in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI).Methods :A total of 118 CHD patients undergoing PCI in our hospital were randomly divided into routine treatment group (n＝58) and nicorandil group (n＝60 ,received nicorandil based on routine treatment ) ,both groups were treated for six months .Endothelial function ,levels of inflammatory factors and myocardial injury markers before and after treatment ,and incidence of major adverse cardiovascular events (MACE) were observed and compared between two groups.Results : Compared with routine treatment group after treatment ,there were significant rise in radial artery reactive hyperemia inner diameter [D1 ,(3-83 ± 0-37) mm vs.(4-01 ± 0-39) mm] ,flow-mediated dilation of bra-chial artery [FMD ,(14-33 ± 1-42 )% vs.(19-35 ± 1-95 )%] ,serum levels of nitric oxide [NO , (70-72 ± 7-82 ) μmol／L vs .(86-15 ± 8-52) μmol／L] and interleukin-10 [IL-10 ,(392-86 ± 40-19) ng／ml vs.(472-75 ± 48-62) ng／ml] ,and significant reductions in serum levels of endothelin-1 [ET-1 ,(70-29 ± 7-39) ng／L vs.(59-62 ± 6-02) ng／L ] ,intercellular adhesion molecule-1 [ICAM-1 ,(195-68 ± 20-48) μg／L vs.(146-72 ± 15-07) μg／L] ,cardiac tropo-nin I [cTnI ,(0-471 ± 0-071) ng／ml vs.(0-222 ± 0-052) ng／ml] ,creatine kinase isoenzyme MB [CK-MB ,(27-62 ± 3-72) U／L vs.(14-79 ± 1-52) U／L] ,mean platelet volume [MPV ,(10-26 ± 1-06) fl vs.(9-75 ± 0-95) fl] ,high sensitive C reactive protein [hsCRP , (5-36 ± 0-63 ) mg／L vs.(3-08 ± 0-27 ) mg／L ] , in-stent restenosis rate (20-69% vs.1-67%) and incidence rate of MACE (67-24% vs.10-00%) in nicorandil group ,P＜0-05 or ＜0-01-Conclusion : Nicorandil can improve postoperative endothelial function ,reduce inflammatory reaction ,protect myo-cardial cells with good prognosis in CHD patients undergoing PCI ,which is worth extending .
ABSTRACT
The microbial flora of fungi,bacterial and actinomycetes in full autotrophic ammonium removal reactor and activated sludge was analyzed,and the amount of nitrite-oxidizing bacteria and ammonia-oxidizing bacteria was also compared.The result showed that the population,species,species number and dominates of microorganisms in full autotrophic ammonium removal reactor were different from that in activated sludge.In full autotrophic ammonium removal reactor,the amount of ammonia-oxidizing bacteria was increased remarkably which indicated that the accumulation of ammonia-oxidizing bacteria was a remarkable feature of full autotrophic ammonium removal system.