ABSTRACT
OBJECTIVE@#To compare the therapeutic effect on type 2 diabetes mellitus (T2DM) complicated with angina pectoris of coronary heart disease between the combined therapy of acupuncture and western medication and the simple administration of western medication.@*METHODS@#A total of 134 patients with T2DM and angina pectoris of coronary heart disease were randomly divided into two groups, i.e. an acupuncture plus medication group (67 cases, 3 cases dropped off) and a medication group (67 cases, 4 cases dropped off). The routine western medication was used according to symptoms in the patients of both groups. In the acupuncture plus medication group, on the base of medication, acupuncture was applied to Jianshi (PC 5), Quchi (LI 11), Neiguan (PC 6), etc. The needles were retained for 20 min in each treatment and 3 treatments of acupuncture were required weekly. The treatment was given consecutively for 8 weeks in the two groups. Separately, before and after treatment, the symptom scores of TCM were observed and the indexes were detected, including glycolipid metabolism [fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), glucosylated hemoglobin (HbA1c), triacylglycerol (TG) and total cholesterol (TC)], islet β cell function [homeostasis model assessment-β (HOMA-β), homeostasis model assessment-IR (HOMA-IR), fasting insulin (FINS) and insulin sensitivity index (ISI)], cardiac function indexes [cardiac output (CO), early diastolic peak velocity/late diastolic peak velocity (E/A), left ventricular end diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF)], as well as electrocardiogram QT dispersion (QTd). Besides, the clinical therapeutic effects were compared between the two groups.@*RESULTS@#After treatment, the TCM symptom scores and the values of FPG, 2hPG, HbA1c, TG, TC, HOMA-IR, FINS, E/A and LVEDD as well as QTd were all lower than those before treatment in the two groups (@*CONCLUSION@#The combined therapy of acupuncture and medication is effective in treatment of T2DM complicated with angina pectoris of coronary heart disease. Such therapy effectively improves glucolipid metabolism, islet β cell function, cardiac function and myocardial blood supply. Its curative effect is better than the simple administration of western medicine.
Subject(s)
Humans , Acupuncture Therapy , Angina Pectoris/etiology , Blood Glucose , Coronary Disease/drug therapy , Diabetes Mellitus, Type 2/drug therapy , Stroke Volume , Ventricular Function, LeftABSTRACT
BACKGROUND: The edge load contact caused by joint separation causes great stress concentration and then produces a large amount of wear. The edge contact caused by hip joint separation is a dynamic process of femoral head touching the rim of the acetabulum and sliding into the acetabulum quickly, so a dynamic contact mechanical model is needed. OBJECTIVE: To obtain the dynamic mechanical simulation model of ceramic acetabulum under the edge load contact, so as to provide the contact mechanics foundation for the wear analysis of hip joint under the condition of edge load, and provide theoretical basis for prosthesis design and surgeon operation. METHODS: By using 3D modeling software SolidWorks and dynamic simulation software ADAMS, edge load contact dynamics simulation model of ceramic femoral head and acetabular cup was established to verify the edge load contact deformation by numerical method. The effects of acetabular abduction angle and initial separation distance on edge load contact were analyzed. RESULTS AND CONCLUSION: (1) The contact stiffness coefficient used in the model is reasonable and effective. This model can be used to study the parameters that influence the edge load contact of hip joints. (2) The excessive cup inclination angle and initial separation distance will increase the severity of the edge load. (3) Acetabular cup inclination angle and initial separation distance are two important factors that affect the edge load contact.