ABSTRACT
Nanotechnology has shown obvious advantages in the field of medical treatment and diagnosis. Through the encapsulation of nano carriers, drugs not only enhance the therapeutic effect and reduce toxic and side effects, but also become intelligent responsive targeted drug systems through the modification on the surface of nano carriers. However, due to the obstacles in relevant basic research, production conditions, cost, clinical trials, and the lack of pharmacokinetic research on various drug loading systems, few nano systems have been used in therapy. In order to solve the above problems, this paper reviewed and analyzed the research progress of nano carriers in drug delivery, including their auxiliary role and characteristics, types and functions, pharmacokinetics, application prospects and challenges.
ABSTRACT
AIM: To investigate the significance of optical coherence tomography ( OCT ) and fundus fluorescein angiography ( FFA) in patients with high myopia macular degeneration. ●METHODS:A total of 62 cases ( 104 eyes ) of high myopia macular degeneration patients with OCT and FFA data from Department of Ophthalmology in Jan. 2014 to Sep. 2015 were retrospectively analyzed. ● RESULTS: Highly myopic macular degeneration patients with FFA type, OCT classification had significant correlation (r=0. 599, P0. 05). The higher FFA type, the smaller ametropia degree, BCVA values, the longer ocular axial length. FFA type patients with foveal thickness determination values were not statistically significant (P>0. 05). ● CONCLUSION: High myopic macular degeneration patients with OCT and FFA results have a certain degree of correlation. However, it′s benefit to combine both of them for further diagnosed and treatment of patients.