Secondary Squamous Cell Carcinoma of the Oral Cavity after Nasopharyngeal Carcinoma / Journal of the Korean Cancer Association, 대한암학회지

Purpose@#The main goal of this study was to analyze the prognosis of secondary oral squamous cell carcinoma (SCC) with a comparison with sporadic oral SCC by a matched-pair design. @*Materials and Methods@#Records of patients with surgically treated primary oral SCC were reviewed, and a total of 83 patients with previous history of radiotherapy for nasopharyngeal carcinoma (NPC) were retrospectively enrolled. A matched-pair study was performed, each NPC survivor was matched with two sporadic oral SCC patients by age, sex, primary tumor site, adverse pathologic characteristics, disease stage, neck node status, and tumor stage. The overall survival (OS) and disease-specific survival (DSS) rates were calculated by the Kaplan-Meier method; independent prognostic factors were evaluated by the Cox proportional hazards method. @*Results@#Compared with sporadic oral SCC patients, NPC survivors were less likely to be smokers (p=0.004), perineural invasion and lymphovascular invasion were more common in NPC survivors (both p < 0.001). The 5-year OS and DSS rates in NPC survivors were 47% and 54%, respectively; the 5-year OS and DSS rates in sporadic oral SCC patients were 62% and 67%, respectively; the difference was significant (both p < 0.05). In survival analysis, disease stage remained to be independent prognostic factor for both the OS and DSS. @*Conclusion@#NPC survivors had worse OS and DSS than sporadic oral SCC patients, NPC survivors were less likely to be smokers, but had higher opportunity of perineural invasion and lymphovascular invasion. Disease stage was the most important predictor for the survival in NPC survivors.

Clinical analysis of 24 cases of carotid body tumor / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>To study the clinical diagnosis and preoperative management of carotid body tumor.</p><p><b>METHODS</b>A total of 24 cases with carotid body tumors underwent surgery from 2003 to 2013 were reviewed. The clinical and imaging features, treatment and prognosis were retrospectively evaluated. Five of the 24 patients were males and 19 were females. Twenty-three cases were benign and one case was malignant. Seven of the 24 patients had bilateral tumors.</p><p><b>RESULTS</b>Nineteen of twenty-four patients underwent digital subtraction angiography (DSA) and temporary balloon occlusion (TBO) test, and one case of them was positive in the test. Twenty-three benign case were treated with operation. The malignant one treat with biopsy. Three cases underwent resection of tumors with both the internal and external carotid arteries without carotid reconstruction, and none of the three patients died or presented with hemiplegia after operation. Twenty-three benign cases were followed up for 6-122 months, the median was 75 months. The malignant patient died 6 months after operation.</p><p><b>CONCLUSION</b>TBO and DSA are reliable and practical methods to determine the safety of carotid ligation and can be used as routine preoperative examinations.</p>

Clinical observation of intra-operative PTH assay in hyperparathyroidism due to parathyroid tumors / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the clinical manifestations and diagnostic method of hyperparathyroidism due to parathyroid tumors and to evaluate the intra-operative detection of parathyroid hormone in surgical treatment.@*METHOD@#Thirty-seven cases with functional parathyroid tumors from January 2003 to October 2012 were retrospectively analyzed. The clinical manifestation, examination and operation method, changes of parathyroid hormone before and after operation were collected.@*RESULT@#All cases were definitely diagnosed before operation. The sensitivity and the positively predictive values of neck ultrasonography were 86.5% and 97.6% respectively, and the same data of Tc-99m-MIBI was 97.2% and 100.0%. The PTH levels declined by 84.9% ten minutes after tumor resecting compared with the level before operation. The serum calcium and PTH returned to normal levels and symptomatic relief occurred after operation.@*CONCLUSION@#Recurrent bone disease, long-term urinary calculus and obscure gastrointestinal symptoms were common symptoms of hyperparathyroidism due to parathyroid tumors. The neck ultrasonography and Tc-99m-MIBI were suitable for location of parathyroid tumors. Surgical operation was an effective treatment for parathyroid tumor. Intra-operative PTH assay would be able to ensure the radical excision and the operative safety for functional parathyroid tumors.

Clinical analysis of granulomatous capillary hemangioma of the larynx / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To improve the acknowledgement of clinician on granulomatous capillary hemangioma of the larynx.@*METHOD@#Collect patients in our hospital who were treated with granulomatous capillary hemangioma of the larynx from 2006 to 2011 and the clinical data, treatment and follow-up consequence were retrospectively analyzed.@*RESULT@#There are 10 cases of laryngeal granulomatous capillary. Eight patients with hoarseness as the chief complaint, in the eight patients three cases associated with foreign body sensation in the throat. One patient with hemoptysis as the main performance. The left one patient to hospital because of pharyngeal foreign body sensation associated with blood in the sputum. All were treated with surgery, there are several cases supplemented by CO2 laser treatment, so far no case of postoperative recurrence.@*CONCLUSION@#Granulomatous capillary hemangioma is a benign, vascular proliferation of the skin or mucosa, rather than ture tumor. Recurrence is rare if completely excised. The prognosis is encouraging.