ABSTRACT
Aim: Hospitalised patients have a high risk of developing aspiration pneumonia because of poor oral care and oral microbial flora changes. Chlorhexidine (CHX) solution has been used to reduce inflammation and prevent infections in oral cavity, but it is difficult to use in inpatients. Gel?type antimicrobial agents rather than the liquid form may be effective for the oral management of hospitalised patients. Therefore, we evaluated the in vitro antimicrobial effects of CHX?containing oral gels on aspiration pneumonia?inducing bacteria compared to the CHX solution. Materials and Methods: The experimental products of two oral gel types containing 1% and 0.1% CHX, respectively, were selected. Hexamedine, a 0.12% CHX solution, was used as a positive control. The antimicrobial activity of CHX agents against six pneumonia?causing bacteria and Streptococcus mutans, one of the most common oral bacteria, was comparatively analysed using the agar disk diffusion method. Results: In the disk diffusion assay, the 1% CHX gels showed the highest inhibitory effect on all bacteria. All CHX agents including gels and solution had the highest antibacterial activity against Staphylococcus aureus compared with other bacteria. Conclusions: We confirmed the significant antimicrobial effects of the 1% CHX oral gels on aspiration pneumonia?inducing bacteria. These results suggest that CHX gels may be an effective oral care method for preventing infection in inpatients who have difficulty using the solution.
ABSTRACT
The aim of this study is to assess the effects of professional oral hygiene care in patients with head-and-neck cancer during radiotherapy, a clinical trial was done. Subjects and Methods: Forty patients were randomly assigned to either the experimental or the control group. For the experimental group, professional oral hygiene care, toothbrushing education, and fluoride varnish application were done once per a week, and for control group, only fluoride varnish application was done once per a week for 8 weeks during radiotherapy. Oral examination including plaque and gingival index was done at baseline and after 8 weeks. Results: The results demonstrated that plaque index was improved in the experimental group, but there was no significant difference between groups (P > 0.05). Plague and gingival status were significantly improved in both groups after 8 weeks compared to those of baseline (P < 0.05). Conclusion: Regular dental visit and professional oral hygiene care during radiotherapy were effective in oral hygiene and health among patients with head-and-neck cancer.