ABSTRACT
In this study, we investigated the chemical profile and effects of RW0117 (Artemisia argyi 65 .5 % ethanol extract) on gastric lesions in rats. We optimized and validated a method to obtain the chemical profile of RW0117. We then investigated the antioxidant and anti-inflammatory effects in vivo, and the protective effects on gastric lesions in vivo. The IC50 of 2,2-diphenyl-1-picrylhydrazyl free radical scavenging considering the antioxidant effects of RW0117 was 166.55 μg/mL, and the IC50 of nitric oxide scavenging considering the antiinflammatory effects was 41.16 μg/mL. Oral administration of RW0117 at lower concentrations (25, 50, 100 mg/ kg) had similar or greater effects than the daily intake conversion concentration (115mg/kg) of a health functional food (Avexol® ) in the acetic acid-induced ulcer and the ethanol-induced gastric injury rat models. In addition, oral administration of RW0117 increased the expression of prostaglandin E2 , which enhances the protective effect in the gastric mucosa in the ethanol-induced gastric injury rat model. These results suggest that RW0117 may have potential therapeutic uses in the protection of the gastric mucosa.
ABSTRACT
In this study, we investigated the chemical profile and effects of RW0117 (Artemisia argyi 65 .5 % ethanol extract) on gastric lesions in rats. We optimized and validated a method to obtain the chemical profile of RW0117. We then investigated the antioxidant and anti-inflammatory effects in vivo, and the protective effects on gastric lesions in vivo. The IC50 of 2,2-diphenyl-1-picrylhydrazyl free radical scavenging considering the antioxidant effects of RW0117 was 166.55 μg/mL, and the IC50 of nitric oxide scavenging considering the antiinflammatory effects was 41.16 μg/mL. Oral administration of RW0117 at lower concentrations (25, 50, 100 mg/ kg) had similar or greater effects than the daily intake conversion concentration (115mg/kg) of a health functional food (Avexol® ) in the acetic acid-induced ulcer and the ethanol-induced gastric injury rat models. In addition, oral administration of RW0117 increased the expression of prostaglandin E2 , which enhances the protective effect in the gastric mucosa in the ethanol-induced gastric injury rat model. These results suggest that RW0117 may have potential therapeutic uses in the protection of the gastric mucosa.
ABSTRACT
PURPOSE: To analyze the MR findings of chondroblastoma and peritumoral bone marrow, focussing on the enhancement pattern. MATERIALS AND METHODS: Enhanced MR images obtained from 23 patients with pathologically proven chondroblastoma were retrospectively reviewed by three radiologists. The enhancement pattern was classified as one of three types: homogeneous, heterogeneous, or peripheral rim, while peritumoral bone marrow enhancement was assigned one of four grades. Correlation between the enhancement pattern and T2 signal intensity of a tumor was analyzed by Fisher's exact test. RESULTS: The enhancement pattern was homogeneous in ten cases, heterogeneous in six, and involved the peripheral rim in seven. In 11 cases, peritumoral bone marrow enhancement was observed. Among the ten instances of homogeneous enhancement the signal intensity seen at T2WI was homogeneously iso or low in six cases, homogeneously high in two, and heterogeneous in two. Among the seven cases in which there was peripheral rim enhancement, the signal intensity observed at T2WI was homogeneously high in three, fluid-fluid level in three, and homogeneously iso or low in one. CONCLUSION: At MR imaging, chondroblastoma shows variable signal intensities and enhancement patterns. The peripheral rim enhancement observed at T2WI correlated with homogeneously high signal intensity or fluid-fluid levels.
Subject(s)
Humans , Bone Marrow , Chondroblastoma , Magnetic Resonance Imaging , Retrospective StudiesABSTRACT
Idiopathic hypereosinophilic syndrome refers to the clinical disorder characterized by persistent eosinophilia and systemic signs of involvement in which specific causative factors for eosinophilia cannot be verified during a certain period. It is primarily a disease of the adult man, but is found very rarely in infancy and childhood. There have been only a few reported cases of this syndrome in association with acute lymphoblastic leukemia but an overt lymphoma has not been described yet. Until now the exact mechanism for malignant transformation of the hypereosinophilic syndrome is not clear. Here the authors experienced a case of idiopathic hypereosinophilic syndrome which evolved to malignant lymphoma in a 17-month-old boy.
Subject(s)
Adult , Humans , Infant , Male , Eosinophilia , Hypereosinophilic Syndrome , Lymphoma , Precursor Cell Lymphoblastic Leukemia-LymphomaABSTRACT
Since Pallister first described 12p tetrasomy syndrome in 1977, approximately 50 patients have been described. Chromosomal study of lymphocyte is normal in most cases, but fibroblasts usually reveal 12p tetrasomy in chromosomal study. We report on a 17-month-old male infant with Pallister-Killian syndrome. He was admitted in our hospital for investigation of developmental delay and myoclonic seizure. He was diagnosed with Killian syndrome by clinical feature and 12p isochromosome in chromosomal study. He had multiple anomalies such as frontal bossing, temporofrontal balding, hypertelorism, simian crease, and accessory nipple. He died at home at 25 months old.