Normal Value of Fetal hemoglobin Concentration in Children

A study of normal value of fetal hemoglobin concentration at each age in 1213 cases (852 patients, 361 normal children) who visited Chonnam university hospital from June 1977 to November 1978 was performed by alkali denaturation method, and following results were obtained. 1) The mean value of Hgb F at each age in normal children group was 65.5+/-1.8% in newborn infants during 24 hours, 40.5+/-1.6% in 1 month, 24.3+/-1.2% in 2 months, 15.3+/-1.4% in 3 months, 4.5+/-1.2% in 1 year 1.3+/-0.5% in 5 years, 0.9+/-0.7% in 10 years, 0.5+/-0.3% in 15 years. 2) The mean value of Hgb F at each age in patients group was 68.6+/-2.5% in newborn infants during 24 hours, 42.5+/-1.7% in 1 month, 22.9+/-1.1% in 2 months, 15.2+/-0.9% in 3 months, 5.5+/-1.0% in 1 year, 1.4+/-0.4% in 5 years, 0.9+/-0.6% in 10 years, 0.6+/-0.2% in 15 years. 3) The mean value of Hgb F at each age in both group was 67.5+/-2.0% in newborn infants during 24 hours, 41.8+/-2.1% in 1 month, 23.4+/-1.9% in 2 months, 15.2+/-1.0% in 3 months, 5.1+/-1.1% in 1 year, 1.4+/-0.8% in 5 years, 0.9+/-0.2% in 10 years, 0.6+/-0.2% in 15 years. 4) No significant correlation was found in the concentration of Hgb F at each age between normal children group and patients group, and either in the concentration of Hgb F at each sex of two groups.

The Clinical Study of Congenital Syphilis in Low Birth Weight Infants

The clinical study was made on 52 cases who had treated for congenital syphilis at Chonnam University Medical School Hospital. Of these, 39 cases were admitted to Pediatric Department of C.U.M.S.H. from Jan. 1971 to Dec. 1978 via out patient dispensary and 13 cases were born in C.U.M.S.H. form Jan. 1974 to Dec. 1978. The results were summarized as followings; 1) 8% of the total low birth weight infants and 0.5% of the infants who weighed over 2,500gm at birth were diagnosed as congenital syphilis. 2) In sex distribution 36 were male and rest of them were female. 3) 70% among congenital syphilitic patients in low birth weight infants had prematurity. 4) The first clinical sympton appeared 89.4% within the fourth week after birth, 53.9% in the first week and 9.6% after the fourth week. 5) The most frequent clinical manifestation was hepatomegaly(79%), next in order of skin manifestaion(72%), anemia(60%), splenomegaly(48%), rhinitis and snuffle(48%). 6) In V.D.R.L. test, 96% of the patient, 98% of the mother and 72% of the father revealed reactive response. 7) Bony changes of roentgenographic examination were detected in 47 cases(90%). 8) 16 cases of congenital syphilitic patients in low birth weight infants(52 cases) and 8 cases of congenital syphilitic patiets who weighed over 2,500gm at birth were died and the most common cause of death in the patients of low birth weight infants was prematurity.

Clinical Studies on Purpura in Children

The following results were obtained through the clinical review of 182 cases who were admitted with purpuric manifestation at the Pediatric Department of Chonnam National University Hospital during the four-year period, January 1975 through Decemver 1978. 1. The incidence was in the order of leukemia 50 cases(27.5%), sepsis 33 cases(18.1%), meningococcemia 33 cases(18.1%), allergic purpura 29 cases(15.9%), aplastic anemia 19 cases(10.5%) and I.T.P. 18 cases(9.9%). 2. By age distribution, 69.2% of the patients was less than 8 years of age. Male to Female ratio was 1.5:1. 3. The most common symptoms were purpura, fever, anemia and epistaxis. 4. In the laboratory findings; Platelet count was below 50,000/mm(3) in I.T.P.(66.7%), leukemia(68.0%), aplastic anemia(89.5%) but was above 150,000/mm(3) in allergic purpura(93.1%). Bleeding time was prolonged above 4min. in thrombocytopenic purpura but was within normal limits in non-thrombocytopenic purpura.