ABSTRACT
Diffuse panbronchiolitis(DPB) is a chronic inflammatory airway disease predominantly affecting respiratory bronchioles, with distinct clinicopathological profiles. It was first described in 1966 by Yamanaka et al. The etiology of DPB is not yet clear, and the natural history of the disease is respiratory failure leading to cor pulmonale and ultimately death. But the long-term use of low-dose macrolide has proven to be highly effective in treating patients with DPB. Usual age at diagnosis is over 40. A few cases of DPB have been reported in Korea since 1992 but there have been no reports in children. We experienced a case of DPB in a 12-year-old girl. Therefore, we report the case with a brief review of the related literature.
Subject(s)
Child , Female , Humans , Bronchioles , Diagnosis , Korea , Natural History , Pulmonary Heart Disease , Respiratory InsufficiencyABSTRACT
PURPOSE: To evaluate the epidemiologic characteristics of aseptic meningitis in Daejeon, Korea from 1987 to 2003. METHODS: A total of 2201 medical records of children with aseptic meningitis admitted to the Catholic University of Korea, Daejeon St. Mary's Hospital, was retrospectively analyzed. RESULTS: The mean annual number of cases was 129, with a higher rate of occurrence in the summer season(May to August, 74.1%). Outbreaks of aseptic meningitis were noted in the years 1990, 1993, 1996, 1997, 2001, and 2002. The age distribution was relatively even, with higher incidences in the 4-7 years group and in the under one year old group. The male-to-female ratio was 2 : 1. Comparing the epidemics of 1997 and 2002, there were no marked differences in age distribution, except in the less than 1 year old age group(11.8% vs. 4.4%), nor in the monthly incidence. Neurologic complications were found in 0.7% of the patients. CONCLUSION: Outbreaks of aseptic meningitis occurred every one to three years in Daejeon, reflecting typical nationwide epidemics that occurred from 1987 to 2003. The incidence of disease in the less than 1 year age group during each epidemic may reflect the herd immunity of the maternal generation.