ABSTRACT
Androgen acts via the androgen receptor and can play a critical role in the development and growth of the prostate and the pathophysiology of prostatic diseases. Testosterone is the most abundant circulating androgen and is converted to dihydrotestosterone (DHT), a more potent androgen, by steroid 5alpha-reductase. There are two 5alpha-reductase isoenzymes, type 1 and type 2, in humans and animals. Type 2 5alpha-reductase predominates in the prostate. While deficiency of type 2 5alpha-reductase causes male pseudohermaphroditism, increased DHT has been implicated in benign prostatic hyperplasia and prostate cancer. The aim of this article is to highlight the significance of 5alpha-reductase in the development and growth of the prostate and pathogenesis of prostatic diseases.
Subject(s)
Animals , Humans , Disorder of Sex Development, 46,XY , Dihydrotestosterone , Growth and Development , Isoenzymes , Prostate , Prostatic Diseases , Prostatic Hyperplasia , Prostatic Neoplasms , Receptors, Androgen , Sexual Development , TestosteroneABSTRACT
The results of 97 transurethral resections of the benign prostatic hypertrophy are compared with 78 open prostatectomies performed from 1971 through 1981. The following results are obtained as below: 1. 33.0% of the patients subjected to TUR and 39.7% of the patients subjected to the open surgery were associated with one or more other genito-urinary or systemic diseases. 2. Weight of the resected prostate was markedly heavier in open surgery than TUR; the mean weight was 53.8 gm. for open surgery and 17.1 gm. for TUR. 3. Less amount of the operative blood loss in TUR was encountered than open surgery; the mean amount of blood loss per patient was 113.6 ml. for TUR and 437.0 ml. for open surgery. 4. Operation time was shorter in TUR than in open surgery; the mean time was 74.8 min. for TUR and 120.2 min. for open surgery. 5. Postoperative complications were significantly fewer in TUR than in open surgery. There seemed no relation between age and complication. In TUR incidence of complications was increased when the operation time was above 60 min. but no relation was found in open surgery between the operation time and complication. 6. Overall mortality rate for prostatectomy was 1.1% ; for TUR 1.0% and for open surgery 1.3%. 7. Duration of the postoperative catheterization was remarkably shorter in TUR than open surgery; the mean duration was 5.9 days for TUR and 10.5 days for open surgery. 8. Duration of the hospital stay was fairly shorter in TUR than in open surgery; the mean duration was 12.2 days for TUR and 18.4 days for open surgery.
Subject(s)
Humans , Catheterization , Catheters , Incidence , Length of Stay , Mortality , Postoperative Complications , Prostate , Prostatectomy , Prostatic Hyperplasia , Transurethral Resection of ProstateABSTRACT
Ureteral duplication is the most common developmental abnormality of the upper urinary tract. The upper pole ureter is often associated with a ureterocele and the lower pole ureter, the V-U reflux. A case of bilateral double collecting system associated with bilateral ureteroceles in a 6-month old Korean male is presented with review of literature.
Subject(s)
Humans , Infant , Male , Ureter , Ureterocele , Urinary TractABSTRACT
Study group consists of 30 cases whose follow-up period is over 6 months among 32 cases of bladder tumors treated with thio-TEPA instillation following TUR during the period from January, 1978 through June, 1981. Control group consists of 25 cases whose follow-up period is over 6 months among 33 cases of bladder tumors treated by TUR only during the period from January, 1971 through December, 1977. Following results were obtained: 1. Recurrence rate: In study group, 30% In control group, 64% 2. Interval between TUR & the first recurrence: In study group, average 8.1 months In control group, average 7.1 months 3. Number of tumors at first recurrence: In study group: 89%: under 2 11%: over 3 In control group: 25%: under 2 75%: over 3
Subject(s)
Follow-Up Studies , Recurrence , Thiotepa , Urinary Bladder Neoplasms , Urinary BladderABSTRACT
Statistical observation was made on in-patients in the Department of Urology, Keimyung University Medical College and Hospital, Taegu, Korea, during the period from August 1, 1970 through July 31, 1980. 1. Among 2,798 cases of in-patients, 2,138 cases were male and 660 cases were female with a ratio of 3.2: 1. Most common diseases were ureter stone (14. 8%), bladder tumor (7.1%) and renal tuberculosis (6.4%) in order. 2. Of 2.798 in-patients, operation was done in 2,226 cases. 3. Of 2,226 operation cases, T.U.R.(15. 1%) was the most common operation: nephrectomy(11. 1%). ureterolithotomy (10. 5%) and hydrocelectomy (7. 1%) were performed.