Study on the Path to Improve Medical Students'Humanistic Quality Based on the Internalization Process / 中国医学伦理学

The formation of medical students' humanistic quality is a process of internalization.Referred to the different conditions that needed in different stages of internalization'process,medical humanistic education should be long-term and focus on practice.In terms of medical students,they should understand and control the existing knowledge structures of humanities,actively absorb the knowledge and theory of medical humanities,have the innovation consciousness and awareness of self-improvement,ultimately to improve the humanistic quality.

Three-dimensional positions and forms of temporomandibular joints in Class II devision 1 malocclusion patients associated with different vertical skeletal patterns / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To evaluate the positions and forms of temporomandibular joints (TMJ) with different vertical skeletal patterns in Class II division 1 patients.</p><p><b>METHODS</b>Cone- beam CT scans of 117 Class II division 1 adolescent patients (including 30 patients with high angle, 58 with average angle and 29 with low angle) were selected and reconstructed using Mimics 10.0 software. Fourteen measurements related to the positions and forms of condyle, forms of fossa and joint spaces were performed.</p><p><b>RESULTS</b>Compared with high and average angle patients, the condyles in low angle patients located more posteriorly and inferiorly [the vertical distances between condyle and S was (20.67 ± 1.99)mm and the antero-posterior distances between condyle and S was (9.15 ± 1.61)mm]. The joint fossae were deeper [the fosse depths was (7.83 ± 1.06)mm]. The angles of posterior joint node bevels were bigger [the inclinations were (28.91 ± 3.94)° ]. The condyles were shorter, thicker, tipped more anteriorly and positioned more posteriorly [the proportions of post-positioned condyles of low angle, average angle and high angle patients were 26%, 4%, 0% respectively].</p><p><b>CONCLUSIONS</b>Class II division 1 adolescents with different vertical skeletal patterns had different forms of fossae, and different positions and forms of condyles.</p>

Analysis of risk factors of death of critical patients treated in emergency department / 中华急诊医学杂志

Objective To study the mortality and risk factors of death of critical patients treated in emergency department for initial stabilization and life support. Method The clinical data of 1240 critical patients from January 2005 to December 2006 were retrospectively analyzed. The patients were divided into death group and survival group. The differences of demographics, symptoms, physical signs and laboratory findings of patients between two groups were analyzed by using univariate and multivariate logistic regression analysis, sex, age, visiting time after attack, the history of chronic diseases, temperature, respiratory rate, heart rate, mean arterial pressure, respiratory dysfunction, circulatory dysfunction, hepatic dysfunction, gastrointestinal dysfunction, renal dysfunction, coagulation disorders, acid base and electrolyte disturbances, lencocyte count,platelet count, Glasgow coma scale (GCS) score and acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ ). Results There were higher mortality and morbidities of patients with diseases of respiratory, digestive, circulatory and nervous systems. The mortality of patients with the history of chronic diseases was higher (P < 0.01) ,and there were more patients with chronic obstructive pulmonary disease(COPD), chronic cardiac insufficiency, diabetes mellitus or cirrhosis of liver in death group (P < 0.05). The mortality of patients with 3 dysfunctional organs was 32.81%, and the mortality of lity of those with five dysfunctional organs was 76.67% . Logistic regression analysis indicated that male gender, age between 46 and 65, respiratory dysfunction, circulatory dysfunction, gastrointestinal dysfunction, hepatic dysfunction, low Glasgow coma scale (GCS) score and high APACHE II score were risk factors of the death of critical patients. Conclusions The mortality of patients with the history of critical diseases is higher. The more dysfunctional organs, the higher mortality is. Age between 46 and 65, male gender, and dysfunction of lung, circulation, gastrointestinal tract,and liver,and low CCS score and high APACHE II score are risk factors of the death of emergency and critical disease.

Synthesis and identification of antigenic conjugates of podophyllotoxin / 药学学报

Aim To synthesize and identify artificial antigen of podophyllotoxin for the production of podophyllotoxin polyclonal antibody. Methods The hapten was synthesized by two different chemical approaches and characterized by TLC, IR, NMR, and MS. Mixed anhydride reaction (MAR) and active ester method (AEM) were used to couple the podophyllotoxin to carrier proteins (BSA and OVA). Characterization of artificial antigens was done by using spectroscopy and electrophoresis. The anti-podophyllotoxin polyclonal antibodies were obtained through immunizing rabbits. Results The results from IR, NMR and MS showed that 4-O-succinoyl podophyllotoxin (hapten) was successfully synthesized. The coupling molar ratios of the hapten and carrier proteins were 88.6 for Hapten-BSA1, 40.3 for Hapten-BSA2, 17.8 for Hapten-OVA1, and 54.2 for Hapten-OVA2. Hapten conjugates coupled with BSA yielded two sets of the specific and affinitive polyclonal antibodies. One set of antibodies showed an IC50 value of 2.21 μg·mL -1 with a detection limit of 0.12 μg·mL -1. Conclusion Antigenic conjugates were artificially synthesized, and based on these artificial antigens, polyclonal antibodies against podophyllotoxin were raised from rabbits immunized with two different immunogens and characterized with an indirect ELISA format.