ABSTRACT
Objective To study the effectiveness of fasudil on the serum high sensitive C-reactive protein (hs-CRP) and serum amyloid A (SAA) in the patients with acute cerebral infarction.Methods 100 patients with acute cerebral infarction were randomly divided into two groups,the control group (n =50 cases) and the treatment group(n =50 cases).The patients in the control group were treated through salvia injection,while the patients in the treatment group were treated through fasudil.They were treated for forteen days.The hs-CRP and SAA in the serum were detected before and after treatment.Results The total efficienties were 92％ in the treatment group and 84％ in the control group.There was a significant difference between two groups(x2 =1.5152,P ＜ 0.05).The treatment group before and after treament with hs-CRP were (11.3 ± 3.7) mg/L,(3.6 ± 1.1) mg/L.The control group before and after treatment with hs-CRP were (10.9 ± 3.5) mg/L,(7.2 ± 2.8) mg/L.Before and after treatment two groups had significant difference (t =14.1053,P ＜ 0.01) ; after the treatment in the two groups had significant diffecence (t =8.4618,P ＜ 0.05).The treatment group before and after treatment with SAA were (17.6 ± 5.2) mg/L,(2.7 ± 0.9)mg/L,control group before and after SAA treatment were (17.1 ± 4.9) mg/L,(5.2 ± 1.8) mg/L.Before and after treatment,two groups had significant difference (t =2.0096,2.0096,all P ＜ 0.01) ; after the treatment in the two groups had significant difference(t =8.7841,P ＜ 0.05).Conclusion Fasudil can improve acute cerebral infarction throughmitigating inflammation.
ABSTRACT
Objective To evaluate the diagnostic value of high resolution ultrasonography in peripheral nerve lesions Methods Sonographic examinations of peripheral nerves with 10 MHz probe were performed in vitro (fresh amputated specimen), in vivo (healthy volunteers), and in 28 patients with peripheral nerve lesions caused by trauma, compression and tumors preoperatively Sonograms were compared with the corresponding intraoperative findings Results The normal nerve displayed and echogenic fascicular texture with round to oval corss sectional structure on both in vitro and in vivo sonograms In traumatic lesions, the interruption of fascicular pattern reflected the disruption of nerve, and ill delineated fascicular pattern indicated nerve adhesion Centrally hypoechoic and peripherally hyperechoic changes were seen in compressive lesions Definitive relations between nerve and tumor were demonstrated in case of nerve tumor The diagnostic rate by ultrasonography was 64% when the intraoperative findings were regarded as criteria Conclusion Ultrasonography is of some diagnostic value and may have great potential to help direct treatment and follow up in peripheral nerve lesions