ABSTRACT
Sentinel lymph node (SLN) is the first group of lymph nodes to receive breast lymph nodes and the first group of lymph node metastasis. It can accurately predict the metastatic status of axillary lymph nodes, which is an important reference factor in the diagnosis and treatment of breast cancer. It has become the first choice for early breast cancer staging. The rapid and accurate intraoperative localization and diagnosis of SLN is of great significance for the choice of operation mode and the improvement of therapeutic effect. SLN location and diagnostic methods are still needed to be investigated. This article reviews various methods in clinic recently.
ABSTRACT
Objective:To analyze the therapeutic efficacy and adverse reaction induced by Jin Long Capsule (JLC) combined with TEC regimen (docetaxel+epirubicin+cyclophosphamide) in neoadjuvant chemotherapy of breast cancer. Methods:A total of 64 patients who had stagesⅡtoⅢbreast cancer were divided into two groups randomly:JLC combined with neoadjuvant chemotherapy group (JLC group, n=32) and conventional neoadjuvant chemotherapy group (control group, n=32). The chemotherapy cycle was 21 d equal-ly. Evaluations of therapeutic effects were made after three cycles of neoadjuvant chemotherapy and consequent operation. Results:The effective powers (complete response+partial response) of the JLC group and the control group were 84.38% (27/32 cases) and 56.25%(18/32 cases), respectively. The difference was statistically significant (P<0.05). The main adverse effects were gradesⅡtoⅢgastrointestinal tract indisposition and myelosuppression. WBC decrease and incidence rate of nausea and vomiting were obviously low-er in the JLC group than in the control group (P<0.05). The life quality of patients in the JLC group was greatly improved than that in the control group (P<0.05). Conclusion:The application of JLC combined with neoadjuvant chemotherapy can improve therapeutic ef-ficacy and reduce the poisonous side effects of chemotherapy, thereby improving the life quality of patients.
ABSTRACT
Objective Using ?-cyanoacrylate to establish the orthotopic transplantation tumor model from the subcutaneous model of human hepatocellular carcinomas(HCC)in nude mice. Methods The subcutaneous animal tumor model was established by transplanting BEL-7402 cell into the subcutaneous of nude mice. Then the orthotopic transplantation tumor model was established by injecting the subcutaneous transplanted tumor into liver(indirect orthotopic model). Results Using ?-cyanoacrylate to establish the indirect orthotopic model successfully and the survival rates of the transplantation tumor were 95.8 %. Conclusion It was compared with the traditional methods that the indirect orthotopic transplantation tumor model by using ?-cyanoacrylate to establish is an easy method with high successful rate and easy to spread.