ABSTRACT
Aim To find a non-invasive diagnostic method for lung cancer with the results almost as accurate as histopathological examinations using HRCT scoring system. Method This study was conducted from December 2006 until March 2008. A total of 55 persons, comprised of 40 male and 15 female patients suspected of having lung cancer, underwent high resolution computed tomography with and without contrast as well as CT-guided transthoracic needle aspiration to obtain cytology specimens. Results Histopathological examinations revealed the existence of lung cancer in 43 patients (78%) and benign lesions in 12 patients (22%). A scoring system was then made based on the similarities of fi ndings from CT and histopathologic examinations. In the the age group of 49 years and above, tumor volume of more than 68 cm3, HU of more than 21, spicula positive, angiogram positive and lymph node positive had a value of respectively 20, 19, 10, 24, 18, and 17 (total score 108). Conclusion This new method to diagnose lung cancer is constantly as accurate as histological findings with a sensitivity of 97.7% and a specifi city of 83,3% and a cut-off score of 35. According to this system, a score of less than 35 indicates that the lesions were benign while a score higher than 35 is suggestive malignant.
Subject(s)
Lung Neoplasms , TomographyABSTRACT
The aim of this study was to assess asthma prevalence in children between 13-14 years of age in East Jakarta. This study is a cross sectional study which surveyed 2234 high school students between the ages of 13 and 14 years in East Jakarta in 2001 using the ISAAC questionnaire. Bronchial challenge test was applied by using methacholine substance to 186 students. Reports based on the ISAAC questionnaire indicate that 7.2% of teenage have had wheezing experience, 4.1% have wheezing within the last 12 months, 1.8% have ever suffered severe asthma attack within the last 12 months, 3.3% have suffered wheezing after exercise, and 6.3% have got night cough while they were not suffering from cold. Prevalence of atopy diseases such as rhinitis and eczema were 14.2% and 3.9%, meanwhile rhinitis and eczema prevalence within the last 12 months according to this study were 10.6% and 2.9% respectively. Statistically, there is a significant correlation between wheezing symptom and atopy (p < 0.05). From indepth questionnaire, a significant value of kappa 0.84 related with wheezing within the last 12 months was found. Bronchial challenge test results indicate that sensitivity was 90%, specificity 83.58%, positive predictive value 68.12% and negative predictive value was 95.73%. Asthma prevalence in East Jakarta at 2001 based on ISAAC questionnaire was 8.9%, and cumulative prevalence 11.5%. The ISAAC questionnaire can be used to study asthma prevalence in children at multicenter in Indonesia.
Subject(s)
Asthma , Adolescent , Prevalence , Surveys and QuestionnairesABSTRACT
Lung cancer is usually seen in patients of middle and old age. The disease is rarely seen in patients under 40 years. In Dharmais Cancer Center Hospital 37 patients of 40 years of age or younger were seen. The number was 5.9% of the total of lung cancer cases that was seen in this hospital in 1994 - 1998. The disease was more dominant among males (male to female ratio 3 : 1), age between 26-40 years. Most of the patients were stage IV (45.7%), chief complaints were dyspnea (58.I%) and pain (32.5%). Nonsmall cell carcinoma was the most frequent histologic type (91.9%), small sell carcinoma was seen in 2.7% and in 5.4% the histologic type could not be determined. The treatment consisted of surgery in 9 cases, radiotherapy in 17 cases and chemotherapy in 5 cases. Fourteen patients (38%) died in hospital, the rest were not followed further.