ABSTRACT
Background: Spinal anaesthesia is one of thecommonest anaesthetic techniques for infra-umbilicalsurgeries. Administration of dexmedetomidine forsedation during spinal anaesthesia is found to prolongthe duration of block. Aim and Objectives: To evaluating the effect of intravenous dexmedetomidine onblock characteristic of spinal anaesthesia withhyperbaric bupivacaine. Material and Methods: Atotalof 120 patients scheduled for various elective surgeriesunder spinal anaesthesia with hyperbaric bupivacainewere included in the study. The patients were dividedinto two groups of each containing 60 subjects. GroupD received 1µg/kg bolus dexmedetomidine over 10minutes immediately after spinal anaesthesia followedby 0.5µg/kg/hr infusion till the end of surgery andGroup S received similar amount of saline. Datacollected include onset of sensory and motor blockade,time for two segmental regression of block, duration ofanalgesia and sedation score were noted. Results:Onset of sensory block was faster in group D(2.38±1.48 min) as compared to Group S (3.03±0.22min). Onset of motor block was significantly faster inGroup D (6.97±0.93 min) as compared to Group S(8.01±0.85 min). Time required for two segmentregression was prolonged in Group D (122.67±7.15min) as compared to Group S (65.76±4.71 min). Totalduration of analgesia was also prolonged in group D(4.29 ±1.04 hr) compared to Group S (2.24±0.29 hr).Conclusion: Intravenous administration of dexmedetomidine prolongs the duration of sensory and motorblockade with arousable sedation.
ABSTRACT
Mucoepidermoid Carcinoma is an epithelial salivary gland tumor which usually occurs in younger patients and females. The following case report deals with a case of mucoepidermoid carcinoma in a 38-year-old male patient who reported with a chief complaint of swelling in the palatal region for 1 year. At first, it was diagnosed as a benign minor salivary gland tumor of the palate. Upon incisional biopsy, an impression was made according to the features present. Complete excision of the lesion was done which was then diagnosed as mucoepidermoid carcinoma. The conflict between whether the lesion was a benign minor salivary gland tumor of the palate or a malignant counterpart, was resolved and confirmed after excisional biopsy.The article focuses on various diagnostic aspects of this tumor and its surgical management
ABSTRACT
The present study was aimed to determine a novel route of synthesis of quinolines and their in vitro antioxidant activities. Synthesis of quinolines is simple, economic, effective and an easy way process has been developed by using the SiO2–Zn-MgO as a novel catalyst. The quinolines antioxidative potential was evaluated using 1,1-Diphenyi-2-Picrylhydrazyl (DPPH), superoxide radical, hydroxyl radical, and hydrogen peroxide radical assay by in vitro methods. Quinolines exhibited highest level of antioxidant activities, and therefore it could be used as antioxidant that may have potential benefits in health and disease management.