Ovarian cyst enlargement in a 14 year old female with persistent ascities, severe hypothyroidism and elevated serum CA-125 level

A 14 year old female complained of abdominal pain and distention with vomiting. The physical exam showed thyroid enlargement and ascites. The imaging evaluation demonstrated a large ovarian cyst. Laboratory tests depicted hypothyroidism and marked elevation of Carbohydrate antigen 125 [CA-125] levels. As the bone age was 10 years, more retarded than the chronological age, Van Wyk and Grumbach syndrome was suspected. Treatment with thyroid hormone was initiated and the condition improved dramatically with disappearance of symptoms and signs 5 weeks later

effect of vitamin C on expression of morphine-induced conditioned place preference in male mice

Background: Dopaminergic and glutamatergic systems play a critical role in expression of morphine-induced place conditioning, while vitamin C, released from glutamatergic neurons, modulates the synaptic action of dopamine and glutamate. This study investigated the effect of vitamin C on expression of morphineinduced place conditioning in male mice

Materials and Methods: In this experimental study, 96 male NMRI mice [20-30g] were randomly divided into 12 groups of 8: control groups received normal saline [10 ml/kg] and treatment groups received morphine [2.5, 5, and 10 mg/kg] and vitamin C [1, 5, and 30 mg/kg] alone and with morphine. The study took place on six consecutive days, consisting of three phases: preconditioning, conditioning, and postconditioning. In the first set, vitamin C alone were administered in conditioning and postconditioning phases to see if they induced conditioned place preference [CPP] or aversion [CPA]. In the second set, mice received vitamin C in postconditioning phase after conditioning with morphine

Results: Different doses of morphine [5 and 10 mg/kg, p<0.001] induced CPP [112.06 +/- 14.44 and 128.65 +/- 16.12 sec, respectively] compared to control group [?9.34 +/- 2.04 sec]. Different doses of vitamin C alone did not induce any significant CPP or CPA. However, coadministration of vitamin C [5 and 30 mg/kg; p<0.01 and p<0.001, respectively] with morphine [5 mg/kg] significantly induced morphine-like CPP [80.4 +/- 9.61 and 56.45 +/- 13.52 sec, respectively]

Conclusion: Low doses of vitamin C induced morphine-like CPP probably by agonistic action on dopaminergic and glutamatergic systems. Therefore, this vitamin may be useful for controlling compulsive drug-seeking behavior in morphine addicts