ABSTRACT
Systemic Lupus Erythematosus is an autoimmune disease characterized by the production of a heterogeneous group of autoantibodies: unavoidable element for diagnosis, prognosis and therapeutic monitoring. The aim of this study was to establish the profile of some autoantibodies in Moroccan lupus patients. This is a prospective study conducted over six months, in the Immunology Laboratory of the Faculty of Pharmacy and Medicine of the University Hassan II of Casablanca, including 30 patients with Systemic lupus erythematosus. The average age of our patients was 34, 6 years, with a female predominance [sex-ratio: 0, 2] Clinical signs were polymorphic, dominated by hematological [25 cases], skin [22 cases], rheumatological [21 cases] and kidney disorders [8 cases]. Immunologically, anti-nuclear antibodies were positive in 77% of cases, and anti-dsDNA in 73, 9% of cases. For soluble anti-antigen antibodies, they were dominated by anti SSA antibodies [52%]. The involvement of anti-dsDNA and anti-SSA in disease activity was deducted, hence the crucial importance of systematic research of these autoantibodies for regular monitoring of lupus patients preventing the occurrence of systemic manifestations