Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add filters








Language
Year range
1.
GJO-Gulf Journal of Oncology [The]. 2015; (19): 28-32
in English | IMEMR | ID: emr-174992

ABSTRACT

Introduction: Malignancies have been reported to occur with increased frequency in chronic lymphocytic Leukemia [CLL] patients. The aim of this study was to describe which second malignancies occur in patients with CLL, whether these malignancies are related to CLL, its treatment, or both. We also attempt to study factors predicting the development of other malignancies


Patients and methods: Between 1995 and 2009, six cases of CLL associated with solid tumor were diagnosed in Hematology Department of Military Hospital of Tunis. The diagnosis of CLL was made by immunophenotyping of peripheral blood circulating B cells, and the diagnosis of solid tumors was made by biopsy with anatomopathological exam and immunohistochemical study


Results: The mean age of patients was 71 years. Five patients were male. The CLL was classified Stage A in one case, Stage B in three cases and Stage C in two cases. Two patients had abnormal karyotype. Three patients have not received specific treatment for their CLL. Solid tumors were represented by skin cancer in three cases, lung cancer in two cases and breast cancer in one case. The median time between diagnosis of CLL and that of solid tumor was 53 months


Conclusion: Patients with CLL have an increased risk of developing a second cancer. Awareness of risk factors could permit early detection


Subject(s)
Humans , Aged , Aged, 80 and over , Female , Male , Response Evaluation Criteria in Solid Tumors , Neoplasms, Second Primary , Review Literature as Topic
SELECTION OF CITATIONS
SEARCH DETAIL