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Journal of Guilan University of Medical Sciences. 2008; 17 (65): 1-6
in Persian | IMEMR | ID: emr-200206

ABSTRACT

Abstract Introduction: Diabetes mellitus is accompanied with a higher incidence of cardiovascular disorders and atherosclerosis. With regard to antidiabetic potential of derivatives of Allium latifolium [AL], the effect of oral administration of this plant on the contractile reactivity of isolated aorta in diabetic rats was investigated during 6 weeks


Objective: Survey the Effect of Feeding of Allium Latifolium on Contractile Reactivity of Aorta of Diabetic rats


Materials and Methods: In this study male wistar rats [n=32] were randomly divided into 4 groups, i.e. control, AL-treated control, diabetic, and AL-treated diabetic groups. For induction of diabetes, streptozotocin [60 mg/kg i.p.] was used. The treatment groups received oral administration of plant-mixed standard pelleted food [6.25%] for 6 weeks. After 6 weeks, contractile reactivity of aortic rings to KCl and nor adrenaline was determined by using isolated tissue setup


Results: Serum glucose level in diabetic group increased during 6 weeks after the experiment as compared with one week before the study [p<0.001] AL treatment of diabetic rats showed a significant hypoglycemic effect [p<0.01]. In addition, the latter group showed a lower contraction to KCl [P<0.05] and nor adrenaline [P<0.01] as compared with diabetic group. Meanwhile, there was no significant difference between control and AL-treated control groups regarding contractile reactivity


Conclusion: use of Oral administration of AL for 6 weeks can attenuate the contractile responsiveness of the vascular system and this may prevent the development of hypertension in diabetic rats

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