Can we use Sorafenib for advanced Hepatocellular Carcinoma [HCC] Child Pugh B?

HCC is the third cause of cancer-related death worldwide and the fifth most common cancer in the world with an increasing incidence in some areas like Europe, USA and the Gulf region. In this study patients with advanced HCC in both group child pugh A and B were treated with sorafenib. This is a retrospective observational study to assess the safety and effectiveness of sorafenib in patients with advanced HCC child pugh A and B who failed local palliative ablation therapy or were not eligible for such therapy. Forty six patients included. In both child pugh A and B group the sorafenib was well tolerated and survival was improved but it was more pronounced in the child pugh A group. This is the first study that includes high percentage [47%] of child B group to be treated with sorafenib. Compared with international data there was improved overall survival in both groups

[Investigation of resonance effect caused by local exposure of extremely low frequency magnetic field on brain signals: a randomize clinical trial]

Some studies have investigated the effects of extremely low frequency magnetic fields [ELF-MFs] on brain signals, but only few of them have reported that humans exposed to magnetic fields exhibit changes in brain signals at the frequency of stimulation, i.e. resonance effect. In most investigations, researchers usually take advantage of a uniform field which encompasses the head. The aim of present study was to expose different parts of the brain to ELF-MFs locally and to investigate variation of brain signal and resonance effect. The subjects consisting of 19 male-students with the mean age of 25.6 +/- 1.6 years participated in this study. Local ELF-MFs with 3, 5, 10, 17 and 45Hz frequencies and 240 microT intensity was applied on five points [T3, T4, Cz, F3 and F4] of participants scalp Separately in 10-20 system. In the end, relative power over this points in common frequency bands and at the frequency of magnetic fields was evaluated by paired t-test. Exposure of Central area by local magnetic field caused significant change [p<0.05] in the forehead alpha band. Reduction in the alpha band over central area was observed when temporal area was exposed to ELF MF. The results showed that resonance effect in the brain signals caused by local magnetic field exposure was not observed and change in every part of the relative power spectrum might occur. The changes in the EEG bands were not limited necessarily to the exposure point