Evaluation and tableting characterization of spironolactone-B-cyclodextrin complex prepared by double compression technique

In this study, double compression technique [slugging] was evaluated to prepare SP-BCD complex. The prepared complex was evaluated by infrared [IR] and X-ray diffraction and compared with solid state complexes prepared from aqueous solution and partitioning technique. The SP-BCD powders were formulated into tablets and evaluated for their physicochemical properties. The aqueous solubility of SP from the prepared complexes and physical mixtures was found to be similar. The IR and X-ray diffraction studies of SP-BCD slugs indicated the presence of a mixture of amorphous, crystalline and inclusion complex. The tablet properties showed variations in hardness and disintegration time values. The dissolution rate of SP from tablets containing slugs was similar to those containing the other SP-BC complexes, while tablets prepared without BCD showed a very slow dissolution rate

Release pattern of dyphylline tablets containing polyion complexes made from chitosan with anionic polymers

With a view to the application of chitosan [CS] for drug delivery, interpolymer complexes of CS with each of carbopol 934 [CP] and carboxymethyl cellulose [CMC] were investigated employing viscosity measurement. The stoichiometry of binding were 1:4 and 1:2 for CS:CMC and CS:CP complexes, respectively. Physical mixtures 50% of each CS:CMC and CS:CP in different ratios including those of their complexes were directly compressed to tablets containing 50% w/w of dyphylline as a model drug. In acid medium, the most precise sustained behavior from CS:CMC and CS:CP matrices were found at ratios of 1:4 and 2:1, respectively, indicating the formation of the complex during dissolution. In phosphate buffer, however, CS disintegrated and released from the physical mixture was dependent on the weight fraction of either CMC or CP. The drug release pattern from increased pH milieu was almost similar to that in acid medium. Even low percentage of matrix [CS:CP and 10% concentration], also showed sustained release effect

Formulation of hydroflumethiazide dispensable tablets

Hydroflumethiazide [HFM] was ground with different weight ratios of PVP or mannitol. IR spectra and X-ray diffraction patterns of HFM in the prepared mixtures were tested. The ground mixtures were formulated into tablets. The solubility of HFM in distilled water from the formulated tablets was also determined. The results revealed that drug crystals have changed to an amorphous state by the procedure of grinding with either PVP or mannitol. IR showed changes in the drug spectrum after grinding. Tablets containing the ground mixtures exhibited higher dissolution rate compared with those containing the physical mixtures of the components. The drug solubility from tablets containing 20% of either PVP or mannitol [which gave the highest dissolution rate] was 5.78 or 5.10 times the solubility of untreated drug. Accordingly, tablets containing 25 mg HFM can be completely dissolved in about 15 ml of distilled water. This may be useful for immediate production of liquid dosage forms for pediatric and children therapy and for patients suffering from difficulties in swallowing