[Double blind clinical trial the comparison aspirin effect at two different time of circadian on 24 hours blood pressure mean women at preeclampsia risk]

Gestational hypertension and preeclampsia are important maternal and fetal - infant complications and the second cause of maternal death [after embolism]. This study is a clinical trial was done on 64 women at preeclampsia risk. The patient came under study with convenience method .The control group I taking placebo in the morning, control group 2 taking placebo at bedtime, experimental group 1 taking 100 mg aspirin in the morning and experimental group 2 taking 100 mg aspirin at bedtime. This intervention started at 12 to 16 weeks of gestation and continued up to 32 weeks. Blood pressure monitoring device was recorded patient's blood pressure before and after taking drug at the end of each month for 24 hours until delivery. Clinical information of the patients was collected and registered in special form and was analysis with statistical method analysis variations at the level of 5% by using SPSS version 16. The age of participants were between 17-42 years with mean 28.71 SD +/- 5.87%.The systolic blood pressure mean at the time of enteringwere computedlo6.20 +/- 4.936% and the diastolic blood pressure 61.909 +/- 5.373%. 24 hour Blood reassure mean of the sampling who take aspirin before bedtimewas significantly less than control groups and group taking aspirin in the morningduring pregnancy [for systole and diastole P <0.001]. The effect of taking aspirin at bedtime is moreon blood pressure mean reduction compared with taking it in the morning and placebo in women at preeclampsia risk

[Comparison of two methods of fixation with Carnoy's solution and 96% ethyl alcohol in pap smear slides]

Cervical carcinoma is a significant health care problem world wide. The Papanicolaou test is the most common effective tool available for early detection of cervical cancer. Blood could have a negative influence on the quality of the pap smear. Good fixation reduces red blood cells of the back ground slides and can help to improve this technique. One of the effective solutions for hemolyzing red blood cells is using Carnoy's solution. The aim of this study was to compare two methods of fixation with Carnoys solution and 96% ethyl alcohol in bloody pap smear slides. This study was done on 450 bloody slides of pap smear prepared from cervical cells of 225 women who referred for annual screening of cervical cancer from 1384-85 in Zeinabie and Faghihi hospitals in Shiraz. In each case, after observation of contact bleeding, two samples with conventional pap smear method were prepared. In the first method one of the samples was fixed in 96% ethyl alcohol for 5 minute and another sample was fixed with Carnoys solution for 20 minutes. Then the slides were stained with papanicolaou method and were evaluated by two pathologists. Collected data were analyzed with Fishers exact test, Pearson chi-square test and Independent sample T test. Results of this study showed that presence of squamous cells and glandular cells in Carnoys fixed slides was more than alcohol-fixed slides. The reduction of red blood cells of the back ground of slides and increase of slide clearance in Carnoys fixed slides were more than alcohol fixed slides. The diagnosis of inflammatory cells and pathogen microorganisms in Carnoy's fixed slides were more than alcohol fixed slides but diagnosis of epithelial cells and glandular cells abnormalities in two methods was not statistically significant. Carnoys stain can be effectively used for proper fixation of Pap smear slides