ABSTRACT
Objective: This research investigated on in vitro ffree-radical scavenging property for the alcoholic extract from Pseudarthria viscida Linn. [Leguminosae]. Different antioxidant models of screening were employed
Material and methods: The alcoholic root extract of P. viscida was screened for free radical scavenging potential using 2, 2- azinobis- [3- ethyl-benzothiazoline- 6- sulphonate] [ABTS], 1, 1- diphenyl, 2- picrylhydrazyl [DPPH], superoxide and nitric oxide radicals
Results: Concentration dependent free radical scavenging activity was observed for the extract in which a concentration of 1000 micro g/ ml exhibited maximum scavenging activity against the radical cation, 2,2- azinobis- [3- ethylbenzothiazoline- 6- sulphonate] [99.41%], followed by superoxide radical using Riboflavin- Ethylene diamine tetra-acetic acid [97.60%] and the nitric oxide model [82.50%]. However, only moderate scavenging activity was observed with the 1, 1- diphenyl, 2- picryl hydrazyl radical [59.61%] at the same concentration
Conclusion: All the results of the in vitro antioxidant models of screening revealed the potent free-radical scavenging of the alcoholic root extract of Pseudarthria viscida Linn
ABSTRACT
To evaluate the antidiabetic effects of the alcoholic extract of leaves and stem of I. auamoclit employing a short term study. A short tem study was carried as a preliminary investigation to evaluate the antidiabetic effect of the alcoholic extract of leaves and stem of I. quamoclit and its normoglycemic and antihyperglycemic activity in streptozotocin [STZ[- nicotinamide induced non insulin-dependent diabetes mellitus rats using Glucose Tolerance Test t[GTT]. Graded doses [250 and 500 mg/kg] of the alcoholic root extract suspended in gum acacia were administered to normal and experimental diabetic rats. A significant fall in the blood glucose level of extract-treated animals was seen after 1 hour, indicating its hypoglycemic activity. Continuous blood glucose lowering activity was observed up to 4 hours of administration in normoglycemic and diabetic rats. The results were compared with those following the administration of standard oral hypoglycemic agent, glibenclamide. Administration of the alcoholic extract caused statistically significant decrease in the blood glucose levels of normal and diabetic rats as compared to the normal control and diabetic control groups respectively. Longer duration studies of Ipomoea quamoclit on chronic models may contribute toward the development of a potent antidiabetic drug