ABSTRACT
Neuropathic pain arising from sciatic nerve ligation [SNL] injury can result in increased sensitivity to both noxious [hyperalgesia] and non-noxious stimuli [allodynia]. Some research studies have been shown that the mechanisms underlying neuropathic pain processing differed as a function of gender and gonadal hormone status. In this study, we try to show the effects of nerve injury after gonadectomy in time-course of hyperalgesia that has not been extensively studied. 45 albino male mice weighting 25-35 gr were subjected to Intact, Shamoperated, Sciatic Nerve Ligated, Gonadectomized, and Sciatic Nerve Ligated+Gonadectomized groups. The tail flick latency was measured at set intervals 10[th]-20[th] days for 11 days after surgical operation [peripheral nerve injury by left sciatic nerve ligation and gonadectomy] in all groups by tail flick analgesiometer. The gonadectomized mice responded [7.15 +/- 1.8 sec] significantly faster than intact ones [10.78 +/- 1.43 sec] to a thermal nociceptive stimulus [P