ABSTRACT
BACKGROUND:Knee intra-articular adhesion has a serious impact on the postoperative patient's daily life,but the efficacy of traditional treatment is limited.To reduce knee intra-articular adhesion is the key to improve the expectations of surgery,which is an urgent problem to be solved.OBJECTIVE:To analyze various articles concerning knee intra-articular adhesion,and summarize the research achievements in the last decade,so as to provide new ideas and methods for the prevention of knee intra-articular adhesion.METHODS:The first author retrieved PubMed database using computer and searched the relevant articles published from 2006 to 2016.The keywords were "tissue adhesions,arthrofibrosis,joint stiffness,prevent,treatment".Totally 1 500 articles were retrieved,and finally 59 eligible articles were included in accordance with the inclusion criteria.RESULTS AND CONCLUSION:In recent years,a large number of scholars have found that trauma or surgery can cause knee joint bleeding and inflammation,which result in the increased expression of vascular endothelial growth factor and interleukin-6,enhance the activity of fibroblasts and secrete a large amount of collagen deposition,thereby causing knee intra-articular adhesion.The modification of traditional methods and application of minimally invasive technology have achieved a certain effect on the knee intra-articular adhesion,but there is still a risk for re-adhesion.A remarkable achievement has been obtained in the basic research of preventing knee adhesion with intra-articular drug that can become an effective method for preventing intra-articular adhesion,but its clinical feasibility is still controversial,and further investigation is needed to find the drug possessing exact effect and less adverse reactions.