ABSTRACT
Objective To investigate the effects and traumas of uniportal and two-portal thoracoscopic surgery in treatment for lung cancer. Methods 100 patients with non-small cell lung cancer between May 2013 and December 2016 were collected, reviewed and divided into single-portal thoracoscope group (n = 40) and two-portal thoracoscope group (n = 60). The surgical efficiency of the two groups was recorded, and the differences in serum levels of tumor markers, inflammatory factors and pain stress indexes were compared before and after surgery. Results Differences in surgical success rate, intraoperative ratio of conversion to thoracotomy as well as serum tumor markers CEA, CYFRA21-1, SCC and CA125 levels were not statistically significant between the two groups (P > 0.05). Serum inflammatory factors IL-1, PCT and CRP levels as well as pain stress indexes SP, PGE2, NE and Cor levels of both groups after operation were higher than those before operation (P < 0.05), and serum inflammatory factors IL-1, PCT and CRP levels as well as pain stress indexes SP, PGE2, NE and Cor levels of single-portal thoracoscope group after operation were lower than those of two-portal thoracoscope group (P < 0.05). Conclusion Single-portal thoracoscope can be successfully used in the treatment of lung cancer and is less traumatic.