ABSTRACT
Objective To investigate the main symptoms and the health care consciousness of the menopausal women.Methods From Jul.2013 to Oct.2014,a one-on-one,face-to-face questionnaire was conducted in selected menopausal women in Gynecology Clinic of the Second Affiliated Hospital of Chongqing Medical University.Results There were 583 valid questionnaires overall.349 women had natural menopause,and the average age was(48.7±3.4) years.66.72％ women appeared menstrual disorders in premenopausal stage,presenting longer cycle and fewer menstrual quantity.82.50％ (481/583) women had menopausal symptoms,with hot flashes (57.46％,335/583) as the most,followed by insomnia (50.60％,295/583).Kupperman score showed 7.03％ (41/583)patients were the severe degree.Among the patients with menopausal symptoms,234 cases went to menopause clinics on their own initiative and 36 cases visited other department first and then transferred to menopause clinics.Among patients with college or above degree,51.27％ (101/197)received menopausal hormone therapy (MHT),significantly higher than those with poor educational background.Conclusion Vasomotor symptoms such as hot flashes were still the main symptoms of menopausal syndrome.Although some menopausal patients had intentions to seek medical care by themselves,there sre still some patients lacking health care consciousness,which is more commonly seen in patients with lower level of education.Menopausal education promotion is needed.
ABSTRACT
Objective To study the relationship between the medial artery calcification and expression of core-binding factor alpha 1 (Cbf α-1) and collagen Ⅱ (Col Ⅱ) in chronic kidney disease (CKD) stage 5 patients.Methods Pieces of radial arteries were taken from 40 patients with CKD stage 5 during internal arteriovenous fistula operation.Ten patients with subtotal gastrectomy and normal renal function were chosen as control.The vessels were examined for calcification by von Kossa stain and for the presence of Cbfα-1 and Col Ⅱ by immunohistochemistry.According to von Kossa stain,CKD stage 5 patients were divided into no calcification group,mild-moderate calcification group and severe calcification group.Other related factors including serum calcium,phosphate,intact parathyroid hormone (iPTH),C-reactive protein (CRP),triglyceride(TG),cholesterol(TC) and lowdensity lipoproteins(LDL) were also detected.Results Seventeen (42.5％) of CKD Stage 5 patients showed vascular calcification,while calcification was not found in controls.Most calcification occurred in medial layer.Positive immunohistochemical staining of core-binding factor and Col Ⅱ was found in the smooth muscular cell plasma of medial layer in the vessels with calcification.However,above positive staining was also observed in 78.3％ of no calcification group.But there was little staining in control group.Positive staining score of Cbfα-1 and Col Ⅱ in severe calcification group was significantly higher than that in no calcification group.Same findings were obtained in mild-moderate calcification group,but the difference between them was not statistically significant.CRP and Ca × P were positively correlated with staining score of Cbfα-1 and Col Ⅱ.Serum phosphate was positively correlated with Cbfα-1 (r=0.786,P＜0.01) and Col Ⅱ (r=0.785,P＜0.01) respectively.Conclusions 42.5％ of CKD stage 5 patients in our group shows vascular calcification,which occurrs mainly in medial layer.High expression of Cbfα-1 and Col Ⅱ can be observed in vascular calcification of radial arteries,which is earlier than vascular histological changes.Cbfα-1 and Col Ⅱ may be involved in the development of vascular calcification.