The clinical significance of thymopeptides α1 in the treatment of severe sepsis / 中国生化药物杂志

Objective To investigate the application values of thymosin α1 in severe sepsis.Methods Selected 94 patients with severe sepsis in our hospital from September 2014 to October 2016,were randomly divided into observation group(n=45)and control group(n=49),the control group was given routine treatment,the observation group was given thymosin α1 on the basis of conventional treatment,observed two groups before and after treatment T cell subsets and CD14+monocyte human leukocyte antigen(HLA-DR)and so on.Results The observation group the duration of ventilator use and ICU treatment were(12.51±3.82)d and(15.81±3.18)d,significantly shorter than the control group(P< 0.05).There was no significant difference in 28d mortality between the observation group and the control group; After treatment,the CD14+monocytes HLA-DR,CD3+and CD4+T cells in the observation group were significantly improved than before treatment(P<0.05);The HLA-DR,CD3+and CD4+T cells in the observation group after treatment were(36.04± 8.90)％,(58.93±8.74)％and(43.20±9.90)％,significantly higher than those in the control group(P<0.05);The observation group after treatment TNF-α,endotoxin and CRP respectively(56.40±11.78)ng/L,(27.83±9.98)ng/L and(53.20±9.73)g/mL,significantly lower than the control group(P< 0.05).Conclusion Application of thymosin α1 in the treatment of severe sepsis,which can improve the cellular immune function,adjust the state of inflammatory response,shorten the duration of mechanical ventilation and ICU stay.

Preliminary Study of Nocturnal Breathing Disturbance in Patients of Ischemic Cerebral Stroke with Dysphagia / 中国康复理论与实践

@#Objective To analyze the role of dysphagia during the course of sleep apnea in patients who experienced a first-ever ischemic stroke.Methods According to the video-fluoroscopy,50 patients were divided into two groups:dysphagia and non-dysphagia groups.The effect of different sites and severity of infarction on the breathing disturbance was analyzed,and the possible role of dysphagia was discussed.Results Patients with dysphagia showed more number of OAIs at the acute phase(AHI,20.9;OAI,19.1)than that of non-dysphagic patients(AHI,9.5;OAI,8.6).Multiple correlation analysis found the extent of dysphagia had relationship with the AHI,especially OAI(AHI,P=0.018;OAI,P=0.024).Conclusion The number and type of obstructive apneic events may occur at the acute phase of a first-ever cerebral infarction in patients with pharyngeal muscle alterations secondary to the neurological lesion.