ABSTRACT
Clitoria ternatea belonging to the family Fabaceae, commonly known as Butterfly pea. A wide range of secondary metabolites including triterpenoids, flavonol glycosides, anthocyanins and steroids were isolated from Clitoria ternatea Linn. GC-MS analyses of CHCl3 and EtOAc fractions were performed on Gas Chromatography with mass spectrometer. The aim of the present study was to evaluate the radical scavenging ability, using the stable radical DPPH and anti-diabetic activity in alloxan induced diabetes in albino rats was evaluated from the flowers extract of Clitoria ternatea. The blood glucose level in the different groups was assayed and biochemical parameters were assessed to support the proposed hypothesis. During the experimental period, body weight of all the rats was determined at regular intervals of time. The serum glucose lowering activity was compared with glibenclamide, a standard hypoglycemic drug.
ABSTRACT
Leucas aspera (Willd.) Linn. (Lamiaceae), commonly known as “Thumbai,” is distributed throughout India. This study includes the isolation and characterization of flavonoids present in Leucas aspera flowers were compared wound healing activity with standard soframycin ointment. The plant materials were extracted with 95% methanol, petroleum ether, ethyl acetate, and were subjected to column and TLC chromatographic separation analysis. The chemical constituents isolated from the flowers of L. aspera were characterized based on chemical tests and spectral analysis such as UV and NMR spectroscopy. The structure of the isolated compound was confirmed as baicalein-7-O- β-D-glucuronide (baicalin). It has been investigated for wound healing activity by applying on the albino rats. A slow rate of healing was observed earlier which turns to very rapid on the 12th day. The histopathological examination provided additional evidence for the experimental wound healing studies. Protease is a biochemical marker and pH measured to support the wound healing activity. We conclude that the baicalin isolated with the flowers of L. aspera has better wound healing activity.