ABSTRACT
Bisphosphonates are used in cases of osteoporosis, multiple myeloma, metastatic carcinoma to the skeleton, etc. The patients with nitrogen-containing bisphosphonates are a greater risk for osteonecrosis of the jaws. Osteonecrosis is considered to be one of the side effect of the bisphosphonate the most common affected jaw is mandible. The primary reason for the osteonecrosis of the jaw is basically due to the over suppression of bone turnover rate. Trauma, tooth extractions, and poor oral hygiene is also considered to be another co-factor which precedes the osteonecrosis of the jaw in the patients of bisphosphonate therapy. So, preventive measure as a reduction of oral microbial load and reduction foci of infection is mandatory step before the treatment of bisphosphonate therapy.