ABSTRACT
PURPOSE: To examine heart disease in the systemic lupus erythematosus (SLE) and the association of cardiac abnormalities with anticardiolipin antibodies (ACL). METHODS: Sixteen patients with active SLE disease (group I) were compared with 14 patients without disease activity (group II). A control group of 10 healthy subjects were also evaluated. Patients were subjected to cardiovascular history and physical examination as well as electrocardiogram, thoracic x-ray, two-dimensional and Doppler echocardiogram, and ACL serum determination (ELISA). RESULTS: Myocardial disease characterized by tachycardia, heart failure or echocardiographic abnormalities was shown by 75of patients in the group I. It was associated with ACL positive in 27.2of these patients. Pericardial and valvular involvement were observed in 25of patients in group I. Group II showed myocardial involvement in 21.4of patients without positive ACL. CONCLUSION: Myocardial disease was the most frequent heart involvement in active SLE, and we did not found any association between SLE heart disease and positive anticardiolipin antibodies.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Heart Diseases , Lupus Erythematosus, Systemic/complications , Echocardiography, Doppler , Antibodies, Anticardiolipin , Electrocardiography , Heart Diseases , Chi-Square Distribution , Lupus Erythematosus, Systemic/immunologyABSTRACT
Vinte e cinco pacientes portadores da doença de Poncet foram analisados em suas manifestaçöes clínicas e laboratoriais, com a finalidade de definir critérios de diagnóstico dessa doença. Nos pacientes, foram realizados exames clínico-reumatológico, bacteriológicos, hematológicos, testes imunológicos, estudo radiológico de tórax e articulaçöes e cintilografia osteoarticular. Verificaram-se também as características da tuberculose, doença associada e os tratamentos efetuados. Após a análise da bibliografia e das manifestaçöes clínicas, laboratoriais e evolutivas da nossa série de 25 pacientes, consideramos como critérios de diagnóstico clínico e laboratorial da doença de Poncet os seguintes elementos: a) evidência de tuberculose ativa extra-articular; b) manifestaçöes reumáticas em mais de uma articulaçäo; c) ausência de antecedentes pessoais e familias; d) ausência de comprometimento axial, de coluna vertebral e sacroilíaca; e) resultados inespecíficos dos exames laboratoriais; f) remissäo completa das manifestaçöes reumáticas com a quimioterapia antituberculosa, sem seqüelas articulares permanentes; g) exclusäo de outras doenças reumáticas