ABSTRACT
In the present investigation anti ulcer activity of methanol extract (flower) of the medicinal plant Couroupita guianensis was evaluated in Wistar rats .The experimental rats were divided into four groups (n= 6). The rats were administered with distilled water (Control), Omeprazole (10 mg/kg) (Positive control), MECG (200mg/kg b.w) MECG (400mg/kg b.w) and was followed by the ligation of pylorus region of the stomach for ulcer induction. The stomach of the sacrificed rats were microscopically analysed ,gastric juice parameters such as gastric juice volume, pH, free acidity and total acidity and the biochemical parameters such as carbohydrate ,protein and pepsin level were quantified. The results of the present investigation revealed that the ulcer protection was 86.82% in rats treated with MECG 400 mg/ml and the ulcer score level was found 4.93±0.22 %. .The MECG reduced gastric juice, free acidity, total acidity and PH in the experimental Wistar rats. The total acidity range and free acidity level was recorded 88.50± 5.09 and 61.83±4.71 respectively at the concentration of 400 mg / ml.The biochemical marker enzyme pepsin level was reduced to 15.36 μg/ml when compared with the ulcer induced control group (24.62 μg/ml).
ABSTRACT
The antimicrobial activity of methanol and aqueous extracts of the medicinal plant Cocculus hirsutus was studied using E.coli, Vibrio cholerae, Pseudomonas fluorescence, Klebsiella pneumoniae and Staphylococcus aureus ,Candida gillermontii,Tricophyton rubrum,Tricophyton tansuans,Aspergillus ochraceus,Candida albicans and Rodatrula sp as test micoorganisms.The methanol extract of the plant was found to be more effective against Vibrio cholera(18) and Staphylococcus aureus(17mm) and in the mean time the aqueous extract was found to be more effective against Vibrio cholera(13) and Klebsiella pneumonia (14mm).Both methanol and aqueous extract of this plant was found with no fungal activity against fungal pathogens. Phytochemical screening of the methanol extract of Cocculus hirsutus revealed the presence of alkaloids, steroids, tannins and saponins, which suggests may be responsible for antimicrobial activity. The wound healing potencial of this plant was found to be comparably better than that of the commercial antibiotic Neomycin.