ABSTRACT
Background:The incidence of skin cancer is in rise. It is now more important more than ever to define an accurate aetiology of skin cancer to pave the way for appropriate preventive measures to be taken. Various studies have shown significant and insignificant association of cutaneous malignancy with family and past history of other diseases. But to our knowledge no such studies has been carried out extensively in the North-Eastern region of India. Methods:Across-sectional descriptive study was conducted at Gauwahati Medical College & Hospital, Guwahati, Assam to understand the association of past and family history of diseases. Atotal 150 numbers of newly diagnosed cases of cutaneous malignancy were selected from the outpatient department of Dermatology of the institute over a period of three years. Results:(1) Associated diseases were of 87(58%) minor diseases, 39 (26%) pneumonia,12(8%)eczema, 7(4.67%)pulmonary tuberculosis, 2(1.33%)hepatitis-C infection, 2 (1.33%) venereal diseases and 1(0.671%) shingles (herpes zoster). The effect of pneumonia, eczema, and hepatitis-C infection are highly significant (p=0.00028). (2) In the study, 4(2.67%) patients had family history of cutaneous malignancy. Statistically the effect of family history of cutaneous malignancy of the patients is not significant. (3) In the study 147 (97.99%) patients do not have family history of other major disease. Conclusion: The effect of pneumonia, eczema, and hepatitis-C infection are highly significant in causation of cutaneous malignancy. The effect of family history of cutaneous malignancy of the patients is significant in selectedtype of cutaneous malignancy.
ABSTRACT
Primary cutaneous involvement in T-cell lymphoblastic leukemia is rare in childhood. We present a case of 6-year-old girl admitted to our hospital because of multiple skin lesions. She was looked pale and weak. Generalized lymphadenopathy was present. Complete blood count revealed 216,000/mm3 white blood cell count. Peripheral blood smear showed 80% lymphoblasts. Bone marrow aspiration revealed 96% blastic cells with immunophenotype and morphological characteristics of acute lymphoblastic leukemia (T-ALL) which was confirmed by flowcytometry. ALL BFM -95 remission induction treatment protocol was started. Skin lesion remained same after two month of the cytotoxic therapy. The symptoms became more aggressive and she died after 4 months of treatment.