ABSTRACT
Background: Obesity results in a chronic inflammatory state leading to long term adverse effects. The aim of this study is to evaluate effect of low calorie diet and weight loss on serum level of inflammatory markers in patients with fatty liver disease in Iranian population
Methods: In a clinical trial, 40 patients with fatty liver disease in Gastro-hepathology clinic of Tabriz Imam Reza hospital were introduced to receive a low calorie diet. Serum level of proinflammatory factors [IL-1, IL-6, TNF-alpha and Hs-CRP] were measured and compared before and after an 8 week trial of diet
Results: The mean age of the patients was 45.36+/-10.51 years [range: 23-70]. Nine [22.5%] patients were male and 41 [77.5%] was females. The mean value of weight and body mass index of participants decreased significantly after 8 weeks [a mean decrease of 6.47+/- 3.40 percent in weight]. Weight loss in men was significantly more than women. The mean level of IL-1, IL-6, TNF-alpha and Hs-CRP was significantly decreased after weight loss in both men and women. There was no correlation between amount of weight loss with degree of decrease in inflammatory markers. Decrease of TNF-alpha was significantly more in younger patients
Conclusion: Weight loss with low calorie diet can decrease the level of IL-1, IL-6, TNF-alpha and Hs-CRP of patients with fatty liver during 8 weeks independent from gender and degree of weight loss
ABSTRACT
Several studies and research have shown a higher prevalence of celiac disease [CD] and elevation of serum antibody [AGA-IgA and IgA-tTG and EMA-IgA] in patient with diabetes mellitus type I [T1DM] in versus general and non-diabetic population. Thus screening of CD is recommended in T1DM]. This study was conducted to compare frequency of celiac disease in patients with T1DM and healthy persons. As a case-control study,60 patient with T1DM that reffered to endocrine clinic of Qazvin's Boo-Ali hospital, in nearly one year period were enrolled as case group. 60 non-diabetic healthy subjects with age and sex matched, were selected as control group. Blood levels of Total IgA, AGA-IgA and IgA-tTG were measured in all of them, subjects who had elevated of both AGA-IgA and IgA-tTG underwent an upper GI endoscopy and biopsy was done from distal part of duodenum. Any one in case group hadn't IgA deficiency. 14 subjects in control and 12 subjects in case group had positive AGA-IgA that there was no significant difference between them. 2 subject of case group had positive IgA-tTG. Duodenal biopsy in 1 of 14 cases who had elevated AGA-IgA]1 of 2 cases who had elevated IgA-tTG], revealed total villous atrophy indicating CD [Type IIIC with revised Marsh criteria 2001] and in other cases pathologic findings were normal or with nonspecific changes. Frequency of CD in T1DM in our study is 1.67%. There is not any significant difference between case and control groups in prevalence of Celiac disease. But we conclused that screening with AGA-IgA is not a reliable screening test for CD, because there is not significant difference between T1DM and general population