ABSTRACT
Objective To evaluate the efficacy of niosomal dapsone gel and intralesional meglumine antimoniate with cryotherapy and intralesional meglumine antimoniate in cutaneous leishmaniasis
Methods This was a randomized clinical trial with 73 participants that were divided into two groups including, case group [weekly intralesional meglumine antimoniate and twice a day niosomal dapsone gel] and control group [weekly intralesional meglumine antimoniate with biweekly cryotherapy]. The treatment course continued until 16 weeks or complete cure, whatever occurred earlier and participants were followed up in 4th, 8th, 12th and 16th weeks of the treatment
Results Overall, 68 patients [33 males and 35 female] completed the study. Age, sex, size and duration of the lesions were not statistically different between two groups. At the end of the study, 82.9% of patients in case group showed complete response
Conclusion Niosomal dapsone gel has promising results with fewer adverse effects, so, it can be used as an alternative treatment modality, especially in children and patients with contraindication of systemic drugs