5-Fluorouracil and Scleral Flap Splitting After Trabeculectomy

We introduced a method of splitting the lamellar scleral flap(LSF) after trabeculectomy with 5-fluorouracil(5-FU) to evaluate the postoperative wound strength which may reveal directly th6 antiproliferative effect of 5-FU. An 8-0 nylon sture was placed under the LSF at the time of trabeculectomy and both ends of the suture were drawn out from the conjunctiva. The wound strength was evaluated by pulling out the spitting suture at the end of second week after operation. Seventeen eyes of 16 patients underwent a primary trabeculectomy and placement of a splitting suture. 5-FU was injected subconjunctivally, 5 mg every other day in the eyes during postoperative two weeks. Five(50%) of ten eyes of 5-FU group resulted in LSF splitting(p=0.0407, Fisher's exact test). This result may signify that the LSF splitting suture technique will be a helpful means to investigate the effect of post-trabeculectomy wound healing modulators in the early period postoperatively.

5-Fluorouracil and Scleral Flap Splitting After Trabeculectomy

We introduced a method of splitting the lamellar scleral flap (LSF) after trabeculectomy with 5-fluorouracil (5-FU) to evaluate the postoperative wound strength which may reveal directly the anti proliferative effect of 5-FU. An 8-0 nylon sture was placed under the LSF at the time of trabeculectomy and both ends of the suture were drawn out from the conjunctiva. The wound strength was evaluated by pulling out the spitting suture at the end of second week after operation. Seventeen eyes of 16 patients underwent a primary trabeculectomy and placement of a splitting suture. 5-fU was injected subconjunctivally, 5mg every other day in the eyes during postoperative two weeks. Five (50%) of ten eyes of 5-FU group resulted in LSF splitting (p=0.0407, Fisher's exact test). This result may signify that the LSF splitting suture technique will be a helpful means to investigate the effect of post-trabeculectomy wound healing modulators in the early period postoperatively.

Adhesion Power and Histopathologic Findings After Muscle-scleral Tuck of Extraocular Muscles with Absorbable Suture Material in Rabbits

It was reported that muscle-scleral tuck with nonabsorbable suture material helps to preserve anterior ciliary artery circulation and to prevEnt anterior segment ischemia. The authors measured maximum adhesion power and obsesved histopathologic findings at 1st, 2nd, 4th, and 8th week following a muscle-scleral tuck procedure with absorbable suture material in rabbits. Maximum adhesion powers were increasing with time, 110, 120, 150, and 250gm at each week respectively, and kept enough tension for using absorbable suture material Histopathologic findings demonstrated that inflammatory and foreign body reactions decreased with time, and collagen fibers were proliferated at muscle scleral contact area, and fibers in muscle and sclera connected each other and formed firm adhesion. We concluded that muscle-scleral tuck with absorbable suture material maintained adhesion power enough as a rectus muscle strengthening procedure.

Posterior Chamber Intraocular Lens Implantation in front of the Anterior Lens Capsule during Pars Plana Lensectomy and Vitrectomy

Many patients present simultaneously with visually significant (to the patient and surgeon) lens opacities and vitreoretional disease. Traditional management of this problem has included two operations: vitrectomy followed by cataract extraction or cataract extraction followed by vitrectomy. Visual rehabilitation of aphakic eyes after pars plana vitrectomy is often difficult when anatomic objectives are achieved. Intraocular lens provides more natural and convenient vision. Now, simultaneous cataract extraction and lens implantation during pars plana vitrectomy can be considered. We performed posterior chamber lens insertion in the ciliary sulcus after completion of pars plana lensectomy, vitrectomy, and removal of intraocular foreign body. During pars plana lensectomy, we left the anterior lens capsule and zonules intact. After posterior chamber lens insertion, we removed the central anterior lens capsules from behind the optical component leaving a peripheral rim to support the haptics. The procedure provided good pseudophakic vision.