ABSTRACT
Objective To understand the spatial distribution of hepatitis C in Chongqing and its influencing factors.Methods The surveillance data of hepatitis C in 38 counties in Chongqing from January 2010 to December 2014 were collected,and spatial autocorrelation analysis and spatial regression analysis were conducted respectively by using software GeoDa 1.6.7.Results The reported incidence of hepatitis C in Chongqing ranged from 7.3/100 000 to 13.6/100 000 during 2010-2014,with the annual reported incidence of 10.3/100 000.The global Moran' s I values were 0.478,0.503,0.529,0.438,0.406 respectively (P＜0.05).The local spatial autocorrelation analysis indicated there were 6,4,7,5 and 6 areas with high incidences of hepatitis C in 2010,2011,2012,2013 and 2014 respectively.Spatial regression analysis revealed that the reported incidence of hepatitis C in Chongqing was associated with the urbanization rate (Z=2.126,P=0.033).Conclusions The spatial distribution of hepatitis C in Chongqing from 2010 to 2014 was highly clustered.The hot spot of hepatitis C were mainly in the core areas and extended areas with well-developed economy,however the cold spot were in southeastern ecological reserve area with less developed economy.Urbanization had a certain positive influence on the distribution of hepatitis C in Chongqing.
ABSTRACT
Objective To evaluate the efficacy and safety of olopatadine hydrochloride for the treatment of chronic idiopathic urticaria (CIU). Methods A multicentre, double-blind, randomized, parallel-group, controlled clinical trial was conducted. A total of 144 patients with CIU from 3 research centers were enrolled into this study, and randomly and equally divided into a test group and a control group. The test group administrated olopatadine hydrochloride 5 mg twice a day for 28 consecutive days, while the control group administrated levocetirizine hydrochloride 5 mg in the forenoon and a placebo tablet of olopatadine hydrochloride 5 mg in the afternoon for 28 consecutive days. The symptom score reducing index(SSRI)served as the primary outcome, and global assessment score for efficacy and total response rates as the secondary outcome. Results Totally, 137 patients completed the trial, including 70 in the test group and 67 in the control group. As intention-to-treat analysis showed, there were no significant differences in the total response rate between the test group and control group on day 7 (64.29% (45/70)vs. 56.72%(38/67), P > 0.05), 14(82.86%(58/70)vs. 74.63%(50/67), P > 0.05), or 28(87.14%(61/70)vs. 77.61%(52/67), P >0.05)after start of treatment. The SSRI was significantly higher in the test group than in the control group after 4 weeks of treatment(82.67% ± 22.70% vs. 70.51% ± 32.07%, P 0.05), and adverse reactions mainly included lethargy, dry mouth, fatigue, etc. Conclusion Olopatadine hydrochloride is effective and safe for the treatment of CIU.
ABSTRACT
BACKGROUND: In the past, the incidence rates of infectious diseases,natural epidemic diseases and endemic diseases in three gorges areas were always high. Because the flooded areas of Kaixian was enormous, the population of Kaixian was intensive density, the pollution may harm to the population health after the dam has been established.OBJECTIVE: To predict the influence of the Three-gorges dam on population health in Kaixian County of Chongqing and put forward to scientific evidence of preventive measures through analyzing the main health indicators and influence factors in Kaixian.DESIGN: Cross-sectional study.SETTING: Public Health College of Chongqing Medical University and Disease Controlled Center in Kaixian County of Chongqing.PARTICIPANTS: The survey was conducted in Kai County of Chongqing,from February to May 2004. All disease surveillance data of people in this county was investigated and other people lived in three-gorges area or around area were selected as the controls.METHODS: Collect and sort relevant indicators of social development,population health and public health system of Kaixian and related area to go deep into the representative townships to do some filed investigation,collect water samples of local drainage areas to carry out laboratory quantitative analysis; carry out comparative analysis based on the relevant materials; carry out comprehensive predicting and evaluation to the potential impact on population health of the three gorges engineering by combining the quantitative and qualitative analysis methods.general people in Kai county, Chongqing city and all over the nations durKai county, Chongqing city and all over the nations during 1999 and 2003;ty, Chongqing city and all over the nations during 1999 and 2001: Mortality rates of infants and under-five children were also higher than that average levels of whole country and Chongqing respectively; Multi-indicators showed that the general population health status of Kaixian was great bad,which stood a distinct gap among average levels of the whole country and Chongqing maintained about 250/100 000 or so, which was higher than the national level (190/10 000), however, the incidence rate of infectious diseases of Kaixian was rising year after year, even that of the recent two years has been reached up to more than 1.5 times higher than that of the whole of the water-based infectious diseases, especially the virus hepatitis, was severe. Another potential impact on population health of three-gorge dam is the emergence of natural epidemic diseases and insect-based infectious diseases. Malignant tumor such as hepatocarcinoma.CONCLUSION: We should strengthen current public health system, and cognition to the possible threat on disease epidemic and public health.With the construction of three-gorge dam, it is necessary to speed up establishment of effective measures to reduce predictable influence on population health.
ABSTRACT
Paper analysis plays an important role in teaching improvement as well as in its quality enhancement.We have developed a set of software for analyzing paper qualities,which will make paper analysis efficient,practical and standardizing.
ABSTRACT
Degree of Confidence(?),Validity(E),Item Difficulty(P) and Item Discrimination(D) used in Software System for Paper Quality Analysis play an important role in evaluating the qualities of items and papers.Their usages and meanings are discussed in detail here,and an example is given to illustrate their significance and important roles in items analysis and papers analysis.