ABSTRACT
Background:The increasing incidence of metabolic syndrome has been on the rise especially in urban population and leading to increased risk of cardiovascular disease (CVD) and diabetes mellitus. It has been associated with impairment of pulmonary functions. However, there is limited data regarding the association with individual components of metabolic syndrome and overall effect on components of pulmonary functions.Methods:This is a cross sectional study consisting of 50 subjects with metabolic syndrome. All the subjects underwent pulmonary function tests and the association between different components of metabolic syndrome and pulmonary function were examined using unpairedt-test and Pearson抯 partial correlation coefficient. This data was analysed by using statistical package for the social sciences (SPSS) version12.0.Results:In females, moderate negative significant correlation was seen between forced vital capacity (FVC)and systolic blood pressure (SBP), diastolic blood pressure (DBP),fasting blood sugar(FBS), triglyceride (TG), waist circumference (WC)and body mass index(BMI)whereas positive weak non-significant correlation was seen between FVC and high density lipoprotein cholesterol (HDLC), while no such relation was found with forced expiratory volumein one second (FEV1). In males, negative, moderate significant correlation was seen between FVC and FBS whereas strong, positive, significant correlation was seen between FVC and WC; between FVC and BMI. Negative, moderate, significant correlation was seen between FEV1 and WC; between FEV1 and BMI.Conclusions:Our study concluded that there was a significant impact of FBS and WCon decreasing FVC on both genders with minimally significant impact of other components of metabolic syndrome on FVC with no effect on FEV1 hence indicatinga restrictive pattern of pulmonary function derangement. Hence, further studies with larger sample size isneeded to confirm whether there are direct or indirect mechanisms through which insulin resistance could affect pulmonary function.