A rare case of concurrent multiple primary lung cancer of different histological types.

Occurrence of concurrent multiple primary malignancies with different histopathological presentations of the same organ at the same time is often not diagnosed and rarely reported in the literature. We present a case of multiple primary lung cancers with hepatic metastasis where the patient had a moderately differentiated adenocarcinoma of the right lower lobe and a moderately differentiated squamous cell carcinoma of the right upper lobe.

Evaluation of endoscopic biopsy in gastric lesions with a special reference to the significance of mast cell density.

Various studies have shown the role of mast cells in chronic inflammatory states and in tumor growth. The study is designed to have an idea of the relationship of mast cell density (MCD) to gastric ulcer and cancer, to verify whether mast cell accumulation occurred in the two conditions especially in Indian patients and thus postulate that therapeutic strategies against mast cell mediators could be useful in treatment. Also, we want to review literature and attempt to explain our findings. A total of 240 patients, who underwent their first endoscopy and biopsy for a span of 21/2 years were studied retrospectively. Out of these, 210 cases that were either gastric ulcers or cancer were chosen for this MCD study. Biopsies were sectioned and stained routinely. Toluidine blue stain and copper grid was used to calculate MCD. Student's t-Test was used to calculate the statistical significance of MCD. MCD in benign ulcers was much higher than in control subjects. MCD in well-differentiated cancers showed MCD higher than control. Poorly-differentiated adenocarcinoma showed lower MCD than well-differentiated adenocarcinoma. It was concluded that the accumulation of mast cells in gastric ulcers is an inflammatory response. MCD is increased in well-differentiated gastric cancers, which may be a mast cell mediated immune response or mast cells may have a role in tumor angiogenesis and produce factors for tumor progression. Poorly-differentiated adenocarcinoma apparently lacks mast cell mediated anti-tumor response in some unexplained way.

R study of suicide with special reference to endometrial study in female individuals.

A study was conducted at Bankura Sammilani Medical College, Bankura, West Bengal, on suicide victims whose postmortem examination was performed between 1st January, 2003 and 31st December, 2003. Various epidemiological, aetiological and other related factors were studied. There were 42 males (36.21%) and 74 females (63.79%) among the total victims (n=116). Torture by in-laws for dowry was found to be the commonest predisposing factor for suicide (n=34; 29.31%). Consumption of poison was the commonest method (n=48; 41.38%). Incidence of suicide was at its peak during the month of May (n=18; 15.52%). Endometriums of female subjects of child-bearing age (n=60) were studied under microscope and most of them (n=47) were seen to be in secretory phase at the time of commitment of suicide.

Coexistence of a mature teratoma and mucinous cystadenocarcinoma in the same ovary--a case report.

A case of right sided abdominal lump with pain in a 45 years female was presented. Radiological investigation revealed a multiloculated cystic mass with a few mural nodules arising from right ovary. The tumor was removed by exploratory laparotomy and histopathological examination showed coexistence of dermoid cyst with mucinous cystadenocarcinoma in the same ovary. Left ovary and uterus was healthy and there was no tumor extension or omental deposits. Postoperative period was uneventful.

Disordered structure and function of liver in HIV/AIDS--a study of thirty cases.

To study abnormalities in liver associated enzymes and histology in AIDS patients with common infections like hepatotrophic viruses and mycobacteria. 30 cases of HIV/AIDS were studied for any significant pattern emerging. The male:female ratio was 4.26:1, occupation being long-distance truck drivers (30%); migrant goldsmiths (27%); migrant labourers (24%). Duration of illness from onset was within three months (46%) and the maximum duration was 26 months (2%). The most common presentation was fever (90%), weakness (79%), weight loss (62%) and diarrhoea (62%). The CD4 cell count was between 200-500/microL (33%). LFT showed hyperglobulinemia in patients having CD4 cell count <500/microL. Rise of alkaline phosphatase was seen in 63% with CD4 cell count <200/microL. 66.6% had HBsAg reactivity, 33.3% had positive anti-HCV antibody and 50% had abnormal liver histology. One third of these had systemic opportunistic infections like tuberculosis. No correlation could be made between hepatic histology and LFT.

Childhood malignancies at BS Medical College: a ten year study.

A retrospective study of malignant diseases of childhood was carried out at B. S. Medical College, Bankura, W.B. to know the prevalence. It includes cases detected in this institution during 1990-1999 in the age group of 0-14 years. Cases were identified from previous records. Histopathology slides, stained by hematoxylin and eosin, were recovered and reviewed. Diagnosis were made by morphology. Hematological diagnosis were made by morphology and cyto-chemistry. In total 120 cases were detected. Acute leukemia (39.2%) was the commonest, followed by retinoblastoma (19.2%), lymphoma (10.8%), Wilm's tumor (10%) and rhabdomyosarcoma (9.1%). Brain tumors were not found due to non-availability of Neurosurgical Unit in this institution. Frequency of neuroblastoma was very low, only 2 out of a total of 120. In comparison to studies in Southern India and Western countries retinoblastoma and soft tissue sarcoma are more prevalent here, while there is a much lower prevalence of neuroblastoma.